Exploitation of a
versatile strategy for fabricating a plant protein
adhesive with outstanding adhesion and water resistance is a growing
concern in the ecofriendly wood industry. Herein, a core–shell
nanohybrid elastomer composed of the cellulose nanocrystal (CNC) core
and elastic polyurethane shell is prepared via a co-deposition strategy
and then used as an efficient reinforcer to improve the performances
of soy protein (SP) adhesive. It is found that the core–shell
nanohybrid acts as a multiple cross-linker, giving rise to the construction
of a stable protein adhesive system. Moreover, owing to the nanohybrid
design combining “strong yet tough” qualities, the hard
CNC serves to repair the discontinuous protein adhesion layer for
a rigid and integrated system, while the elastic polyurethane contributes
to energy dissipation, thus endowing the protein adhesive with excellent
overall cohesive strength. Given such synergistic effects, the modified
SP-based adhesive exhibits a significant improvement in both adhesion
and water resistance, particularly achieving a 311.8% increase in
wet adhesion strength compared to that of the pristine SP adhesive.
This work may provide an effective guide for the preparation and practical
application of high-performance plant-protein-based adhesive.
Sensitive detection of cancer cells at extremely low concentrations would greatly facilitate the screening and early diagnosis of cancer. Herein, we present a novel nanopore-based strategy for ultrasensitive detection of Ramos cells (human Burkitt's lymphoma cells), by combining the enzymatic signal amplification with an aerolysin nanopore sensor. In this assay, an aptamer for Ramos cells was prehybridized with a short complementary DNA. The presence of target cells causes the target-aptamer complex to unwind to free the complementary DNA, which would subsequently trigger the enzymatic cycling amplification. This process eventually generated a large number of output DNA, which could quantitatively produce characteristic current events when translocated through aerolysin. The proposed method exhibits excellent sensitivity, and as few as 5 Ramos cells could be detected. With good selectivity, the approach can allow for the determination of cancer cells in human serum, offering a powerful tool for biomedical research and clinical diagnosis.
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