CONUT could easily be calculated from blood examination data. Recently, it has been shown that CONUT is an independent prognostic marker in malignant pleural mesothelioma 22 , resected lung squamous cell carcinoma 23 , gastric cancer 4 , and head and neck cancer 24. However, its role in breast cancer has not been reported. To our knowledge, we firstly attempted to assess the prognostic significance of CONUT in breast cancer patients who received curative resection based on a large study. Materials and Methods Patients and follow-up. A total of 1,364 breast cancer patients who received surgical resection from 2007 to 2010 in West China Hospital of Sichuan University were recruited (Supplementary Dataset 1). The complete preoperative blood cell count was procured within seven days before surgery. The exclusion criteria were as follows: (1) patients who received chemotherapy or radiotherapy before the surgery; (2) patients with inflammatory disease or autoimmune disease; (3) patients who lacked detailed clinicopathological information; (4) male breast cancer patients. Finally, 861 cases were included in the present retrospective study. All the patients were followed up every three months in the first three years, every six months for five years, and annually within 6-10 years after the operation. Clinical checkup , laboratory examination and radiological assessment were included in the follow-up investigations.
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