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Volatile organic compounds (VOCs) from exhaled breath (EB) are considered to be promising biomarkers for lung diseases. A convenient and sensitive point-of-care (POC) testing method for EB VOCs is essential. Here, we developed a POC test paper for the analysis of EB aldehydes, which are potential biomarkers for lung cancer. A probe molecule, 4-aminothiophenol (4-ATP), was anchored on a paper substrate to specifically capture gas-phase aldehydes through the Schiff base reaction. Meanwhile, thin-film reaction acceleration was utilized to increase capture efficiency. By directly coupling the test paper to a mass spectrometer through paper spray, high sensitivity (0.1 ppt) and a wide quantification linear range (from 10 ppt to 1 ppm) were obtained. Analysis of EB from lung cancer patients with the test paper showed a significant increase in several reported aldehyde markers compared to EB from healthy volunteers, indicating the potential of this method for sensitive, low-cost, and convenient lung cancer screening and diagnosis.

It is difficult for structural over-complete dictionaries such as the Gabor function and discriminative over-complete dictionary, which are learned offline and classified manually, to represent natural images with the goal of ideal sparseness and to enhance the difference between background clutter and target signals. This paper proposes an infrared dim target detection approach based on sparse representation on a discriminative over-complete dictionary. An adaptive morphological over-complete dictionary is trained and constructed online according to the content of infrared image by K-singular value decomposition (K-SVD) algorithm. Then the adaptive morphological over-complete dictionary is divided automatically into a target over-complete dictionary describing target signals, and a background over-complete dictionary embedding background by the criteria that the atoms in the target over-complete dictionary could be decomposed more sparsely based on a Gaussian over-complete dictionary than the one in the background over-complete dictionary. This discriminative over-complete dictionary can not only capture significant features of background clutter and dim targets better than a structural over-complete dictionary, but also strengthens the sparse feature difference between background and target more efficiently than a discriminative over-complete dictionary learned offline and classified manually. The target and background clutter can be sparsely decomposed over their corresponding over-complete dictionaries, yet couldn't be sparsely decomposed based on their opposite over-complete dictionary, so their residuals after reconstruction by the prescribed number of target and background atoms differ very visibly. Some experiments are included and the results show that this proposed approach could not only improve the sparsity more efficiently, but also enhance the performance of small target detection more effectively.

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The existing thermal infrared (TIR) ship detection methods may suffer serious performance degradation in the situation of heavy sea clutter. To cope with this problem, a novel ship detection method based on morphological reconstruction and multi-feature analysis is proposed in this paper. Firstly, the TIR image is processed by opening- or closing-based gray-level morphological reconstruction (GMR) to smooth intricate background clutter while maintaining the intensity, shape, and contour features of ship target. Then, considering the intensity and contrast features, the fused saliency detection strategy including intensity foreground saliency map (IFSM) and brightness contrast saliency map (BCSM) is presented to highlight potential ship targets and suppress sea clutter. After that, an effective contour descriptor namely average eigenvalue measure of structure tensor (STAEM) is designed to characterize candidate ship targets, and the statistical shape knowledge is introduced to identify true ship targets from residual non-ship targets. Finally, the dual method is adopted to simultaneously detect both bright and dark ship targets in TIR image. Extensive experiments show that the proposed method outperforms the compared state-of-the-art methods, especially for infrared images with intricate sea clutter. Moreover, the proposed method can work stably for ship target with unknown brightness, variable quantities, sizes, and shapes.

Track initiation for dim small moving target particularly in a heavy clutter environment is a theoretical and technological challenge for diverse tracking systems. The different spatial-temporal characteristics presenting in sequence scans are utilized to recognize target and initialize track in this paper. In spatial domain, the small target mapped in the image is a uniform gray spot other than pixel-sized object with high congregated degree, whereas, the false alarm is independent, irrelative and lower congregated degree. In temporal domain, the target's trajectory projected on image sequence is continuous for the continuity of target motion and will appear in the neighborhood at consecutive instants with the maximum probability, on the contrary, the false alarm is disorderly, and occurs in the neighborhood at consecutive instants is impossible. Based on the spatial-temporal characteristics mentioned above, a track initiation algorithm for dim small moving target based on spatial-temporal hypothesis testing, which consists of neighborhood clustering and trajectory continuity, is derived and analyzed in detail. The theory analysis and experimental results show that this method could effectively initialize the track for dim small moving target in heavy clutter environment.

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