Circular RNA (circRNA) is a novel member of endogenous noncoding RNAs with widespread distribution and diverse cellular functions. Recently, circRNAs have been identified for their enrichment and stability in exosomes. However, the roles of circRNAs from umbilical cord blood exosomes in gestational diabetes mellitus (GDM) occurrence and fetus growth remains poorly understood. In this study, we used microarray technology to construct a comparative circRNA profiling of umbilical cord blood exosomes between GDM patients and controls. We found the exosome particle size was larger, and the exosome concentration was higher in the GDM patients. A total of 88,371 circRNAs in umbilical cord blood exosomes from two groups were evaluated. Of these, 229 circRNAs were significantly up-regulated and 278 circRNAs were significantly down-regulated in the GDM patients. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) biological pathway analyses demonstrated that circRNA parental genes involved in the regulation of metabolic process, growth and development were significantly enriched, which are important in GDM development and fetus growth. Further circRNA/miRNA interactions analysis showed that most of the exosomal circRNAs harbored miRNA binding sites, and some miRNAs were associated with GDM. Collectively, these results lay a foundation for extensive studies on the role of exosomal circRNAs in GDM development and fetus growth.
Tracking operating trains and identifying illegal intruders are two important and critical issues in subway safety management. One challenge is to find a reliable methodology that would enable these two needs to be addressed with high sensitivity and spatial resolution over a long-distance range. This paper proposes a novel monitoring approach based on distributed vibration, which is suitable for both train tracking and incursion detection. For an actual subway system, ultra-weak fiber Bragg grating (FBG) sensing technology was applied to collect the distributed vibration responses from moving trains and intruders. The monitoring data from the subway operation stage were directly utilized to evaluate the feasibility of the proposed method for tracking trains. Moreover, a field simulation experiment was performed to validate the possibility of detecting human intrusion. The results showed that the diagonal signal pattern in the distributed vibration response can be used to reveal the location and speed of the moving loads (e.g., train and intruders). Other train parameters, such as length and the number of compartments, can also be obtained from the vibration responses through cross-correlation and envelope processing. Experimental results in the time and frequency domains within the selected intrusion range indicated that the proposed method can distinguish designed intrusion cases in terms of strength and mode.
Distributed static and dynamic sensing is demonstrated with an ultra-short fiber Bragg grating (USFBG) array. The USFBGs serve as the sensors and reflection mirrors at the same time. Distributed static sensing is performed by demodulating the strain-induced or temperature-induced wavelength shift of each USFBG. Dynamic vibration sensing is realized based on phase variation between two adjacent USFBG reflected pulses. Static temperature and dynamic vibration are applied to the sensing ultra-short FBG array simultaneously. The experiments show that the temperature measurement from 30 °C to 80 °C is achieved successfully. And dynamic sensing of nε scale vibration and 12.5 kHz acoustic wave are demonstrated at a sampling rate of 50 kHz.
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