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Nemonoxacin 500 mg once daily for 7-10 days is as effective and safe as levofloxacin for treating adult CAP patients in terms of clinical cure rates, microbiological success rates, and safety profile. ClinicalTrials.gov identifier: NCT01529476.

Wake structure and sediment deposition behind models of submerged vegetation with and without flexible leaves The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Citation Zhenghong, Hu et al. "Wake structure and sediment deposition behind models of submerged vegetation with and without flexible leaves.

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The Earth's rotation undergoes changes with the influence of geophysical factors, such as Earth's surface fluid mass redistribution of the atmosphere, ocean and hydrology. However, variations of Earth Rotation Parameters (ERP) are still not well understood, particularly the short-period variations (e.g., diurnal and semi-diurnal variations) and their causes. In this paper, the hourly time series of Earth Rotation Parameters are estimated using Global Positioning System (GPS), Global Navigation Satellite System (GLONASS), and combining GPS and GLONASS data collected from nearly 80 sites from 1 November 2012 to 10 April 2014. These new observations with combining different satellite systems can help to decorrelate orbit biases and ERP, which improve estimation of ERP. The high frequency variations of ERP are analyzed using a de-trending method. The maximum of total diurnal and semidiurnal variations are within one milli-arcseconds (mas) in Polar Motion (PM) and 0.5 milli-seconds (ms) in UT1-UTC. The semidiurnal and diurnal variations are mainly related to the ocean tides. Furthermore, the impacts of satellite orbit and time interval used to determinate ERP on the amplitudes of tidal terms are analyzed. We obtain some small terms that are not described in the ocean tide model of the IERS Conventions 2010, which may be caused by the strategies and models we used or the signal noises as well as artifacts. In addition, there are also small differences on the amplitudes between our results and IERS convention. This might be a result of other geophysical excitations, such as the high-frequency variations in atmospheric angular momentum (AAM) and hydrological angular momentum (HAM), which needs more detailed analysis with more geophysical data in the future.

Floating Production, Storage and Offloading (FPSO) system has been used widely in the offshore oil and gas industries worldwide. In recent years, FPSO concept has been deployed in deep and ultra-deepwater field development including West of Africa, Offshore Brazil, and Offshore China. Meanwhile, more and more deepwater risers have been deployed from concept to offshore installation. Compared to other type deepwater floaters (e.g. Spar, TLP, Semisubmersible), the severe motion characteristics of an FPSO makes the riser concept selection and design much more challenges. Other constraints imposed by field reservoir properties (e.g. high temperature\high pressure), disconnection requirements for early production FPSO system, and significant increase in water depth even exclude some riser concepts. This paper presents detailed evaluation of potential deepwater riser concepts applicable for an FPSO. Among the deepwater concepts, steel catenary risers (SCR), flexible risers, hybrid risers have been successfully deployed to FPSO application. In addition, there are also other viable riser concepts for FPSO application including lazy wave SCR, Tension Leg Riser (TLR), Hybrid ‘S’ Riser System (HySR), Hybrid Catenary Riser (HCR), and more to come. The evaluation of deepwater riser concepts for FPSO application is conducted in terms of technical feasibility, design constraints, track records, fabrication, offshore construction, and cost with focus on the existing and field proven riser concepts. Technical challenges and technology gaps are highlighted. The technical feasibility of some of the riser concepts for certain FPSO application has been demonstrated through analysis and calculation. Novel ideas have been generated for particular requirements. Particular attention is paid to the discussion with the application to offshore China. This paper shows the steel riser and hybrid riser are the most viable ones for deep and ultra-deepwater FPSO. Flexible riser and hybrid riser are the preferred solution for FPSO in China.