No abstract

No abstract

Current surrogate modeling methods for time-dependent reliability analysis implement a double-loop procedure, with the computation of extreme value response in the outer loop and optimization in the inner loop. The computational effort of the double-loop procedure is quite high even though improvements have been made to improve the efficiency of the inner loop. This paper proposes a single-loop Kriging (SILK) surrogate modeling method for time-dependent reliability analysis. The optimization loop used in current methods is completely removed in the proposed method. A single surrogate model is built for the purpose of time-dependent reliability assessment. Training points of random variables and over time are generated at the same level instead of at two separate levels. The surrogate model is refined adaptively based on a learning function modified from time-independent reliability analysis and a newly developed convergence criterion. Strategies for building the surrogate model are investigated for problems with and without stochastic processes. Results of three numerical examples show that the proposed single-loop procedure significantly increases the efficiency of time-dependent reliability analysis without sacrificing the accuracy.

Proper handling of missing data is important for many secondary uses of electronic health record (EHR) data. Data imputation methods can be used to handle missing data, but their use for analyzing EHR data is limited and specific efficacy for postoperative complication detection is unclear. Several data imputation methods were used to develop data models for automated detection of three types (i.e., superficial, deep, and organ space) of surgical site infection (SSI) and overall SSI using American College of Surgeons National Surgical Quality Improvement Project (NSQIP) Registry 30-day SSI occurrence data as a reference standard. Overall, models with missing data imputation almost always outperformed reference models without imputation that included only cases with complete data for detection of SSI overall achieving very good average area under the curve values. Missing data imputation appears to be an effective means for improving postoperative SSI detection using EHR clinical data.

No abstract

Time-dependent reliability analysis requires the use of the extreme value of a response. The extreme value function is usually highly nonlinear, and traditional reliability methods, such as the first order reliability method (FORM), may produce large errors. The solution to this problem is using a surrogate model of the extreme response. The objective of this work is to improve the efficiency of building such a surrogate model. A mixed efficient global optimization (m-EGO) method is proposed. Different from the current EGO method, which draws samples of random variables and time independently, the m-EGO method draws samples for the two types of samples simultaneously. The m-EGO method employs the adaptive Kriging–Monte Carlo simulation (AK–MCS) so that high accuracy is also achieved. Then, Monte Carlo simulation (MCS) is applied to calculate the time-dependent reliability based on the surrogate model. Good accuracy and efficiency of the m-EGO method are demonstrated by three examples.

No abstract

No abstract