Abstract. The aqueous outflow system (AOS) is responsible for maintaining normal intraocular pressure (IOP) in the eye. Structures of the AOS have an active role in regulating IOP in healthy eyes and these structures become abnormal in the eyes with glaucoma. We describe a newly developed system platform to obtain high-resolution images of the AOS structures. By incorporating spectral domain optical coherence tomography (SD-OCT), the platform allows us to systematically control, image, and quantitate the responses of AOS tissue to pressure with a millisecond resolution of pulsed flow. We use SD-OCT to image radial limbal segments from the surface of the trabecular meshwork (TM) with a spatial resolution of ∼5 μm in ex vivo nonhuman primate eyes. We carefully insert a cannula into Schlemm's canal (SC) to control both pressures and flow rates. The experimental results demonstrate the capability of the platform to visualize the unprecedented details of AOS tissue components comparable to that delivered by scanning electron microscopy, as well as to delineate the complex pressure-dependent relationships among the TM, structures within the SC, and collector channel ostia. The described technique provides a new means to characterize the anatomic and pressure-dependent relationships of SC structures, particularly the active motion of collagenous elements at collector channel ostia; such relationships have not previously been amenable to study. Experimental findings suggest that continuing improvements in the OCT imaging of the AOS may provide both insights into the glaucoma enigma and improvements in its management.
A micrometer‐sized fuel cell based on Nafion/poly(vinyl pyrrolidone) nanowires is presented. The high‐performance micro fuel cell containing a single NPNW proved easy to fabricate and delivered reproducible results. Values for the open‐circuit voltage, maximum current‐density, and power density were orders of magnitude higher than those of traditional fuel cells (see figure). Micro fuel cell assemblies may have future applications in integrated self‐powered nanodevices.
This paper presents an investigation on the humidity sensitivity of deposited multi-walled carbon nanotube (MWCNT) networks using ac dielectrophoresis (DEP) between interdigitated electrodes (IDEs). MWCNTs dispersed in ethanol were trapped and enriched between IDEs on a Si/SiO2 substrate under a positive DEP force. After the DEP process, the ethanol was evaporated and the MWCNT network on a substrate with IDEs was put into a furnace for repeated thermal annealing. It was found that the resistance stability of the network was effectively improved through thermal annealing. The humidity sensitivity was obtained by measuring the resistance of the MWCNT network with different relative humidity at room temperature. The experimental results show the resistance increases linearly with increasing the relative humidity from 25% to 95% RH with a sensitivity of 0.5%/%RH. The MWCNT networks have a reversible humidity sensing capacity with response time and recovery time of about 3 s and 25 s, respectively. The resistance is dependent on temperature with a negative coefficient of about −0.33%/K in a temperature range from 293 K to 393 K.
A structure similar to a field effect transistor with two isolated top electrodes comprising the source and drain and a lower substrate electrode as the gate was used for the dielectrophoresis-based assembly of zinc oxide nanowires. The results reveal that the assembly of nanowires is significantly affected by the gap distance between the two top electrodes as well as the magnitude and frequency of the applied electric field. Gate assisted assemblies using direct current and alternating current dielectrophoresis were also investigated and determined to improve the assembly effect of nanowires.
In this paper, we present a nanoelectromechanical oscillator with a single semiconducting zinc oxide nanowire (ZnO) doubly clamped and suspended on two metal electrodes by which the piezoelectric property on the growth of the ZnO nanowire along the c-axis, [0001], is characterized by the resonant frequency shift of the oscillator. We report that the resonance of the nanowire oscillator can be detected in ambient air and the effective piezoelectric coefficient on the growth of a ZnO nanowire along the c-axis, [0001], is significantly larger than that of bulk (0001) ZnO.
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