Background Lungs from patients with coronavirus disease 2019 (COVID-19) have shown typical signs of acute respiratory distress syndrome (ARDS), formation of hyaline membrane mainly composed of fibrin and ‘ground-glass’ opacity. Previously, we showed plasminogen itself is a key regulator in fibrin degradation, wound healing and infection. Aim We aimed to investigate whether plasminogen can improve lung lesions and hypoxemia of COVID-19. Design Thirteen clinically moderate, severe or critical COVID-19 patients were treated with atomization inhalation of freeze-dried plasminogen. Methods Levels of their lung lesions, oxygen saturation and heart rates were compared before and after treatment by computed tomography scanning images and patient monitor. Results After plasminogen inhalation, conditions of lung lesions in five clinically moderate patients have quickly improved, shown as the decreased range and density of ‘ground glass’ opacity. Improvements of oxygen saturation were observed in six clinically severe patients. In the two patients with critical conditions, the oxygen levels have significantly increased from 79–82% to 91% just about 1 h after the first inhalation. In 8 of 13 patients, the heart rates had slowed down. For the five clinically moderate patients, the difference is even statistically significant. Furthermore, a general relief of chest tightness was observed. Conclusion Whereas it is reported that plasminogen is dramatically increased in adults with ARDS, this study suggests that additional plasminogen may be effective and efficient in treating lung lesions and hypoxemia during COVID-19 infections. Although further studies are needed, this study highlights a possible hope of efficiently combating this rapid epidemic emergency.
Few studies have examined the relationship between personality traits and social networking sites (SNSs) with a dominant concentration on the personality alterations under SNSs influence. The relationship between personality and privacy control was less focused and discussed. In order to figure out the internal mechanism of such link among youth SNSs users, the Theory of Planned Behavior (TPB) was extended by including Five-Factor Model of Personality to explore how personality traits interact with privacy control behavior on SNSs. The investigation using the theoretical method mentioned led to several hypotheses which were later assessed by an online study conducted within randomly chosen college students ( N = 201) from two randomly chosen universities in China. This sampling strategy was designed to mimic the situation of targeted research population in the most reasonable way. The results suggested neuroticism and openness predicted SNSs privacy. Neuroticism and openness predicted “networked privacy” was also found. Theoretical implications of these findings were addressed.
ObjectivesThe aim of this study was to analyze the progression of the audiometric pattern of serial screening tests in companies with hearing conservation program (HCP) to clinical audiometric tests to identify individuals more susceptible to develop cardiovascular diseases (CVDs). The procedure is based on the analysis of various audiometric patterns that have been demonstrated to have a statistically significant relation to certain CVDs. Identifying these individuals, based on pattern progression of hearing loss, could result in earlier detection to prevent disease or decrease its morbidity.Study designUsing the data from the clinical and screening audiograms, pattern analysis was performed and statistical analysis using Fisher's exact test, odds ratios and P values were used to calculate the confidence intervals.MethodsThe analysis was based on potential risk factors related to CVD in 29 cohorts of 10,105 subjects. Of these, a total of 704 subjects also had clinical audiometric tests and examination by an ENT to verify the exactitude of the screening test questionnaire and pattern relation with the clinical audiogram.ResultsA first analysis was made on 704 subjects who had clinical evaluation and clinical audiometric tests showed results comparable to those of Friedland. A correlation between the questionnaire of the clinical and the self‐reporting screening tests questionnaires was performed and showed a correlation between the following risk factors: diabetes, hypertension, hyperlipidemia and smoking. Analysis of the progression of audiometric patterns suggested a relationship with the predictive probabilities of developing CVDs.ConclusionProgression toward low‐frequency hearing loss patterns provides early identification of patients whose audiometric pattern progression suggests increased probability of developing CVDs. The treating physician, by prescribing further investigations, could potentially prevent or reduce the morbidity of these diseases.Level of EvidenceIII
Both EU and US PI paricalcitol dosing strategies effectively reduced iPTH levels in Chinese subjects with SHPT, with minimal impact on Ca and P levels.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.