Plasminogen Improves Lung Lesions and Hypoxemia in Patients with COVID-19

Wu, Yuanyuan; Wang, Ting; Guo, Chunying; Zhang, Dongmei; Ge, Xiaojing; Huang, Zhaoxing; Zhou, Xianshan; Li, Yinping; Qing-zhen, Peng; Li, Jinan

doi:10.2139/ssrn.3552628

Cited by 5 publications

(4 citation statements)

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“…Six patients with severe infection had improvement in oxygen saturation, five patients with moderate infection had radiological improvement of pneumonia, and two critical patients with hypoxemia had improvement in saturation within an hour. [10] The limitations of this study are the small sample size, nonrandomized design, and mortality not being evaluated as an endpoint.…”

Section: Hydroxychloroquine/chloroquine and Azithromycinmentioning

confidence: 97%

“…Plasminogen is a key regulator in fibrin degradation, wound healing, and infection. [10] A study from China with 13 patients who had moderate-tosevere COVID-19 infection were treated with atomization inhalation of free-dried plasminogen (10 mg OD for moderate and 10 mg BD for severe infection). Six patients with severe infection had improvement in oxygen saturation, five patients with moderate infection had radiological improvement of pneumonia, and two critical patients with hypoxemia had improvement in saturation within an hour.…”

Section: Hydroxychloroquine/chloroquine and Azithromycinmentioning

confidence: 99%

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COVID-19 Management: What We Need to Know?

Dhanushkodi

Kulkarni

2020

Indian Journal of Medical and Paediatric Oncology

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Section: Hydroxychloroquine/chloroquine and Azithromycinmentioning

confidence: 97%

Section: Hydroxychloroquine/chloroquine and Azithromycinmentioning

confidence: 99%

COVID-19 Management: What We Need to Know?

Dhanushkodi

Kulkarni

2020

Indian Journal of Medical and Paediatric Oncology

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“…ARDS patients have been shown increased levels of plasminogen. Studies suggest that during COVID-19 infections supplementary plasminogen may be effective in handling lung lesions and hypoxemia [29].…”

Section: Treatment Of Hypoxemia In Covid-19mentioning

confidence: 99%

Life Threatening Hypoxemia Associated with COVID-19 (Review)

Ahmed,

Hashim

2023

CRMI

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COVID-19, which has become a pandemic is caused by coronavirus and led to severe acute respiratory syndrome. Its complication include respiratory incompetence, damage in the muscles of the lung and heart , problems in nervous system and kidney or death. One of the characteristic symptoms of COVID-19 is the low levels of oxygen in patients' blood, a condition known as hypoxemia. Patients with hypoxemia often show the following symptoms: coughing wheezing, difficulty in breathing, headache, feeling disoriented, cyanosis in which the skin, lips, or fingernails become blue colored, even though hypoxemia is diagnosed by some tests, such as analysis of blood gas and pulse oximetry, caution should be considered when pulse oximetry interpreted, because of shifting in the left-sided of the oxyhemoglobin dissociation curve. Hypoxemia causes acute respiratory distress syndrome, that includes inflammation and edema, leadings to impairment in the alveolar homeostasis, modification in the physiology of lung resulting in vascular thrombosis, endothelial inflammation and pulmonary fibrosis, therefore any tardiness in diagnosis and introducing proper treatment can led to mortal outcomes. In this review we present hypoxemia as one of the symptoms resulting from infection with COVID-19 infection, focusing on their types, causes and possible treatment for this condition.

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“…An indirect harm to the heart may also occur by hypoxemia caused by COVID-19 infection. There are pieces of evidence to prove that hypoxia plays a significant role in the cardiovascular risk development [63,64]. Moreover, COVID-19 patients represent low levels of lymphocyte, albumin, potassium, and eosinophil [65].…”

Section: Cardiovascular Systemmentioning

confidence: 99%

SARS-CoV-2 (COVID-19): New Discoveries and Current Challenges

et al. 2020

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SARS-CoV-2 (COVID-19) has today multiplied globally and various governments are attempting to stop the outbreak of the disease escalation into a worldwide health crisis. At this juncture, readiness, candor, clarity, and partaking of data are of paramount importance to speed up factual evaluation and starting pattern control activities, including serendipitous findings. Owing to the involvement of COVID-19, many facts regarding virulence, pathogenesis, and the real viral infection source and/or transmission mode still need to be addressed. The infected patients often present clinical symptoms with fever, dyspnea, fatigue, diarrhea, vomiting, and dry cough, as well as pulmonary, infiltrates on imaging. Extensive measures to decrease person-to-person transmission of COVID-19 are being implemented to prevent, recognize, and control the current outbreak as it is very similar to SARS-CoV in its clinical spectrum, epidemiology, and pathogenicity. In response to this fatal disease and disruptive outbreak, it is extremely vital to expedite the drug development process to treat the disease and vaccines for the prevention of COVID-19 that would help us defeat this pandemic expeditiously. This paper sums up and unifies the study of virological aspects, disease transmission, clinically administered techniques, therapeutics options, managements, future directions, designing of vaccines, and news dissemination pertaining to COVID-19.

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Plasminogen Improves Lung Lesions and Hypoxemia in Patients with COVID-19

Cited by 5 publications

References 20 publications

COVID-19 Management: What We Need to Know?

COVID-19 Management: What We Need to Know?

Life Threatening Hypoxemia Associated with COVID-19 (Review)

SARS-CoV-2 (COVID-19): New Discoveries and Current Challenges

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