The inflammasome is a protein complex composed of a variety of proteins in cells and which participates in the innate immune response of the body. It can be activated by upstream signal regulation and plays an important role in pyroptosis, apoptosis, inflammation, tumor regulation, etc. In recent years, the number of metabolic syndrome patients with insulin resistance (IR) has increased year by year, and the inflammasome is closely related to the occurrence and development of metabolic diseases. The inflammasome can directly or indirectly affect conduction of the insulin signaling pathway, involvement the occurrence of IR and type 2 diabetes mellitus (T2DM). Moreover, various therapeutic agents also work through the inflammasome to treat with diabetes. This review focuses on the role of inflammasome on IR and T2DM, pointing out the association and utility value. Briefly, we have discussed the main inflammasomes, including NLRP1, NLRP3, NLRC4, NLRP6 and AIM2, as well as their structure, activation and regulation in IR were described in detail. Finally, we discussed the current therapeutic options-associated with inflammasome for the treatment of T2DM. Specially, the NLRP3-related therapeutic agents and options are widely developed. In summary, this article reviews the role of and research progress on the inflammasome in IR and T2DM.
As ITU-R Recommendations is widely implemented for countries all over the world, the role and status of ITU-R Recommendations are increasingly prominent in the field of radio engineering. ITU and ITU-R Study Groups are summarized. Furthermore, the operating mode of the third study group, and the input documents are interpreted in detail. Lastly, from both wireless system design and electromagnetic compatibility analysis perspective, all of 79 P-series Recommendations are analyzed and classified, and the main contents of each Recommendation are summarized. The above research promote P-series Recommendations are widely used in China.
Abstract. Currently the radio spectrum resource has become increasingly scarce. Evaluating the usage of frequency bands with existing radio services, strengthening management of allocated resource and improving the spectrum utilization have been becoming an important way of improving spectrum management level. In particular, it is urgent to evaluate the efficiency of spectrum usage for International Mobile Telecommunication (IMT) Systems which is in great spectrum demand. In this paper, an evaluation indicator model is proposed according to the current situation of IMT Systems spectrum usage. The set of evaluation indicators is different from those of the conventional mobile communication network which is generally used for the operator network planning and network optimization. The study of evaluation model in this paper comes from spectrum manager's perspective. Firstly, this paper introduced investigation of spectrum management at home and aboard, then described the proposed evaluating indicators, finally we creatively combined entropy method with sample data based on the model .It can be seen that the proposed evaluation model is reasonable and helpful to support relevant spectrum management work.
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