Herein, the performance of scintillator is the critical key to the X-ray imaging quality and accounts for the operation cost fundamentally.CsI: Tl and Bi 4 Ge 3 O 12 (BGO) have been employed successfully to commercial X-ray detectors [16,17] for their outstanding light yield with high spatial energy resolution (8-10 lp mm −1 ) and strong mechanical properties. [18] Although commercial scintillator as CsI: Tl possesses many advantages, a fatal drawback of CsI: Tl is the humid sensitivity. [19] When CsI: Tl is exposed to humid air, the absorbed water molecules affect the crystal structure, which leads to the declination of light yield performance of the corresponding scintillator and further deteriorates the X-ray imaging capacity of the detector. [13] In addition, the complex preparation process and long growth period of single crystal scintillator materials as BGO also challenges their practical application. [22] Notably, the halide perovskites, including single crystals, [20][21][22] wafer, [23][24][25] film, [26][27][28] crystallites, [29][30][31] exhibit compelling X-ray absorption and intense radiation luminescence (RL). Researchers devote their great enthusiasm to develop record-breaking detection limit and fast light decay for rendering the halide perovskites promi sing semiconductors in X-ray detection and imaging. [32] Successively progress has been achieved, nevertheless, issues that obstructs the application of halide perovskites in terms of their long-term instability, especially the photo-stability, moisture resistance, and thermal stability, has not been well addressed so far. [17,33,34] Hence, the exploration of scintillators that are easily synthesized, robust stable in ambient environment, and endurable for long-term operation is a persistent intriguing focus both for fundamental science and practical application.In this work, the in situ growth of CdS quantum dots (QDs) inside a robust amorphous matrix is realized by means of a facile heat treatment procedure, which presents an excellent RL performance under X-ray irradiation. Moreover, the uniform distribution of the precipitated CdS QDs embedded within the matrix endows a high transparency and homogeneous RL output. Herein, the as-explored CdS QDs glass-ceramic (GC) scintillator possesses a decent stable performance under an irradiation dose reaches 1 mGy air s −1 with a recorded spatial resolution of 10 lp mm −1 . Furthermore, it is demonstrated Scintillators, converting the absorbed high-energy X-ray photons into to visible ones, have been used in fields as medical diagnostics, radiation dosimetry, and security inspection. Commercial bulk scintillators generally suffer from time-consuming production, high-cost operation, and deteriorated performance especially exposed to humidity. Here, in situ precipitated CdS quantum dots (QDs) within the transparent glass matrix are achieved feasibly. The CdS QDs glass-ceramic (GC) is explored to be a superior scintillator with an outstanding weather resistance. A profound radioluminescence behavior and lo...