Cardiovascular health interacts with cognitive and psychological health in complex ways. Yet, little is known about the phenotypic and genetic links of heart-brain systems. Using cardiac and brain magnetic resonance imaging (CMR and brain MRI) data from over 40,000 UK Biobank subjects, we developed detailed analyses of the structural and functional connections between the heart and the brain. CMR measures of the cardiovascular system were strongly correlated with brain basic morphometry, structural connectivity, and functional connectivity after controlling for body size and body mass index. The effects of cardiovascular risk factors on the brain were partially mediated by cardiac structures and functions. Using 82 CMR traits, genome-wide association study identified 80 CMR-associated genomic loci (P < 6.09 × 10-10), which were colocalized with a wide spectrum of heart and brain diseases. Genetic correlations were observed between CMR traits and brain-related complex traits and disorders, including schizophrenia, bipolar disorder, anorexia nervosa, stroke, cognitive function, and neuroticism. Our results reveal a strong heart-brain connection and the shared genetic influences at play, advancing a multi-organ perspective on human health and clinical outcomes.
A fundamental ability for humans is to monitor and process multiple temporal events that occur at different spatial locations simultaneously. A great number of studies have demonstrated simultaneous temporal processing (STP) in human and animal participants, i.e., multiple ‘clocks’ rather than a single ‘clock’. However, to date, we still have no knowledge about the exact limitation of the STP in vision. Here we provide the first experimental measurement to this critical parameter in human vision by using two novel and complementary paradigms. The first paradigm combines merits of a temporal oddball-detection task and a capacity measurement widely used in the studies of visual working memory to quantify the capacity of STP (CSTP). The second paradigm uses a two-interval temporal comparison task with various encoded spatial locations involved in the standard temporal intervals to rule out an alternative, ‘object individuation’-based, account of CSTP, which is measured by the first paradigm. Our results of both paradigms indicate consistently that the capacity limit of simultaneous temporal processing in vision is around 3 to 4 spatial locations. Moreover, the binding of the ‘local clock’ and its specific location is undermined by bottom-up competition of spatial attention, indicating that the time-space binding is resource-consuming. Our finding that the capacity of STP is not constrained by the capacity of visual working memory (VWM) supports the idea that the representations of STP are likely stored and operated in units different from those of VWM. A second paradigm confirms further that the limited number of location-bound ‘local clocks’ are activated and maintained during a time window of several hundreds milliseconds.
Emergency response is a complex activity involving many actors and heterogeneous spatial data. Two of the major challenges are the integration and extraction of these data and their transmission to emergency management actors. Although significant progress has been made regarding the systemic and syntactic heterogeneity of data in this context, semantic heterogeneity remains insufficiently addressed. Here, we discuss the possibility of applying the ontology to resolve semantic heterogeneity in emergency response. We propose a concept for a solution to the semantic interoperability problem in emergency management using an ontology by presenting a case study.
A growing body of evidence has suggested that time, from early to late, or from past to future, was represented in a spatially oriented mental time line. However, little is known about its characteristics. The present study provided the first empirical evidence to explore the symmetry of spatial representations of past and future in the mental time line. Specifically, we compared the Spatial-Temporal Association Response Codes (STARC) effects and distance effects of past and future in four experiments. Results showed that for near past and near future, STARC effects were similar (Experiment 1). For distant past, the STARC effect was significant, but not for distant future (Experiment 2). Furthermore, the distance effect in the past was significantly stronger than in the future (Experiments 3, 4). These findings supported the idea that time points are not evenly distributed in mental time line. Spatial representations of the past and the future are asymmetric, and the spatial representation of past seems stronger than future. The logarithmic pattern of internal spatial representation of past or future is also discussed.
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