Objective: The study is to conduct a component analysis of the dynamics of the incidence of BC (BC) in Kazakhstan, taking into account regions. Methods: Primary data were for registered patients with BC (ICD 10 -C50) in the whole country during the period of 2009-2018. Evaluation of changes in BC incidence in the population of Kazakhstan was performed using component analysis according to the methodological recommendations. Results: The study period, 40,199 new cases of BC were recorded. The incidence rate increased from 39.5 ( 2009) to 49.6 in 2018 and the overall growth was 2.8 per 100,000 population of female, including due to the age structure -∑Δ A =+2.99, due to the risk of acquiring illness -∑Δ R =+6.82 and their combined effect -∑Δ RA =+0.31. The component analysis revealed that the increase in the number of patients with BC was mainly due to the growth of the population (Δ P =+31.1%), changes in its age structure (Δ A =+18.0%) and changes associated with the risk of acquiring illness (Δ R =+41.0%). The increase in the number of patients in the regions of the republic is associated with the influence of demographic factors and with risk factors for getting sick, including mammographic screening. Conclusion: Thus, as a result of the component analysis, the role of the influence of demographic factors and the risk of acquiring illness on the formation of the number of patients and the incidence of BC was evaluated, while geographical variability was established. This research was the first epidemiological study of the dynamics of BC in the regional context by the method of component analysis in the population of Kazakhstan. The implementation of the results of this study is recommended in management of anticancer activities for BC.

Objective: The epidemiological features of the cervical cancer (CC) incidence and its spatial and temporal assessment in Kazakhstan were studied. Methods: The retrospective study was done for the period 2009-2018. Descriptive and analytical methods of oncoepidemiology were used. Results: During the study period, 16,441 new cases of CC were registered. The average annual crude and age-standardized incidence rate were 18.6±0.5 and 17.7±0.4 cases per 100,000 population of female, respectively, and their trends tended to increase (Т up =+2.3%; R 2 =0.708 and Т up =+1.9%; R 2 =0.615, respectively). The analysis of ASIR showed unimodal growth with a peak at 50-54 years -45.3±1.1 cases per 100,000 population of female. Trends of ASIR decreased up to 30 years (T down =−1.8%; R 2 =0.111) and 35-59 years (T down =−0.9%; R 2 =0.103), in other age groups the trends increased, and were most pronounced in 40-44 (Т up =+4.1%; R 2 =0.878) and 65-69 years (Т up =+4.4%; R 2 =0.537). Trends in ASR of СС tended to grow in almost all regions, with higher levels in Mangystau (Т up =+4.1%; R 2 =0.482) and Aktobe (Т up =+6.3%; R 2 =0.846) regions. The cartograms of ASR per 100,000 population of female were allocated according to the following criteria: low -up to 16.3, averagefrom 16.3 to 19.2, high -above 19.2. The results of the spatial analysis showed the regions with a higher levels of CC incidence rate per 100,000 population of female: East Kazakhstan (19.8), Aktobe (20.0), Almaty (20.1), Kostanay region (20.9), Atyrau (21.7) regions and Almaty city (22.0). Conclusion: The study of trends of the cervical cancer incidence has the theoretical and practical value: monitoring and evaluation of screening programmes, which are implemented in the country, and conduction of secondary prevention of cervical pathology. Health authorities should consider the obtained results in the in the organization of anti-cancer activities.

Breast cancer is a serious medical problem. The growth of breast cancer is a grave concern, since according to the IARC, about 2.26 million new cases are registered annually, and an increase of 21% -2.74 million is expected in 2030 (Ferlay et al., 2019;Ferlay et al., 2020A;Ferlay et al., 2020B). In the structure of oncological pathology, breast cancer takes the first place (11.7%), followed by lung cancer (11.4%) and colorectal cancer (10%). The incidence rate of breast cancer in the world is 47.8 per 100,000 women. At the same time, high morbidity rates per 100,000 women are observed in such countries as