Background Parkinson disease (PD) is one of the most common neurological diseases. At present, because the exact cause is still unclear, accurate diagnosis and progression monitoring remain challenging. In recent years, exploring the relationship between PD and speech impairment has attracted widespread attention in the academic world. Most of the studies successfully validated the effectiveness of some vocal features. Moreover, the noninvasive nature of speech signal–based testing has pioneered a new way for telediagnosis and telemonitoring. In particular, there is an increasing demand for artificial intelligence–powered tools in the digital health era. Objective This study aimed to build a real-time speech signal analysis tool for PD diagnosis and severity assessment. Further, the underlying system should be flexible enough to integrate any machine learning or deep learning algorithm. Methods At its core, the system we built consists of two parts: (1) speech signal processing: both traditional and novel speech signal processing technologies have been employed for feature engineering, which can automatically extract a few linear and nonlinear dysphonia features, and (2) application of machine learning algorithms: some classical regression and classification algorithms from the machine learning field have been tested; we then chose the most efficient algorithms and relevant features. Results Experimental results showed that our system had an outstanding ability to both diagnose and assess severity of PD. By using both linear and nonlinear dysphonia features, the accuracy reached 88.74% and recall reached 97.03% in the diagnosis task. Meanwhile, mean absolute error was 3.7699 in the assessment task. The system has already been deployed within a mobile app called No Pa. Conclusions This study performed diagnosis and severity assessment of PD from the perspective of speech order detection. The efficiency and effectiveness of the algorithms indirectly validated the practicality of the system. In particular, the system reflects the necessity of a publicly accessible PD diagnosis and assessment system that can perform telediagnosis and telemonitoring of PD. This system can also optimize doctors’ decision-making processes regarding treatments.
A typical predictive regression employs a multitude of potential regressors with various degrees of persistence while their signal strength in explaining the dependent variable is often low. Variable selection in such context is of great importance. In this paper, we explore the pitfalls and possibilities of the LASSO methods in this predictive regression framework with mixed degrees of persistence. With the presence of stationary, unit root and cointegrated predictors, we show that the adaptive LASSO maintains the consistent variable selection and the oracle property due to its penalty scheme that accommodates the system of regressors. On the contrary, conventional LASSO does not have this desirable feature as the penalty is imposed according to the marginal behavior of each individual regressor. We demonstrate this theoretical property via extensive Monte Carlo simulations, and evaluate its empirical performance for short-and long-horizon stock return predictability.
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