BCL-2 family protein is an important molecular marker of programmed cell death. The form of apoptosis exists in the balance between anti-apoptotic protein and apoptotic protein. The special small molecular protein of apoptotic protein is a window to create small molecular drugs. BH3-only protein is the main simulation form of BH3 drugs. Therefore, this review summarizes the basic structure of BH3-only protein and the related role of protein in apoptosis, which can be widely used in the combined treatment of apoptosis. Besides, this review also updates the relevant latest research news from venetoclax, which was approved for listing by the FDA. The review will contribute to BH3 drugs manufacturing, and will support models to other drugs that could easily treat with different cancers.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.