The main BH3-only proteins in BCL-2 family

Abstract

BCL-2 family protein is an important molecular marker of programmed cell death. The form of apoptosis exists in the balance between anti-apoptotic protein and apoptotic protein. The special small molecular protein of apoptotic protein is a window to create small molecular drugs. BH3-only protein is the main simulation form of BH3 drugs. Therefore, this review summarizes the basic structure of BH3-only protein and the related role of protein in apoptosis, which can be widely used in the combined treatment of apoptosis. Besides, this review also updates the relevant latest research news from venetoclax, which was approved for listing by the FDA. The review will contribute to BH3 drugs manufacturing, and will support models to other drugs that could easily treat with different cancers.