A variety of furo[2,3-e][1,4]diazepin-3-one derivatives
were facilely synthesized through one-pot tandem cyclization/[4 +
3] annulation reactions between enynamides and α-bromohydroxamates.
The reactions proceeded efficiently at room temperature, and various
functional groups were well tolerated. The obtained furo[2,3-e][1,4]diazepin-3(2H)-ones
containing a 7-membered dinitrogen-fused ring might be of biological
and medicinal value. The products could be further derived using convenient
procedures.
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