A novel gold-catalyzed cycloisomerization/[2 + 1]cycloaddition/rearrangement of enyne-amides and sulfur ylides is reported. This strategy enables rapid and efficient construction of a series of α-pyrone derivatives.
A novel catalyst-controlled cycloisomerization/[4+3]cycloaddition sequence of readily available acyclic enyne-amides and crotonate-derived sulfur ylides is reported. This strategy enables the rapid and efficient construction of a series of bicyclic 2,3-furan-fused...
Based on a novel umpolung strategy, an efficient and highly enantioselective cascade aldol/cyclization/tautomerization of the 2-(2-oxoindolin-3-yl)malononitrile to active carbonyl compounds with excellent diastereo-and enantioselectivity has been developed. Also, various enantio-enriched multifunctional dispiro[2-amino-4,5dihydrofuran-3-carbonitrile]bisoxindoles with adjacent spiro-stereocenters were conveniently obtained by this novel methodology. Also, the dispiro[2-amino-4,5-dihydrofuran-3-carbonitrile]bisoxindoles were easily transformed into structurally complex molecules without any effect on the diastereo-and enantioselectivity.
A variety of furo[2,3-e][1,4]diazepin-3-one derivatives
were facilely synthesized through one-pot tandem cyclization/[4 +
3] annulation reactions between enynamides and α-bromohydroxamates.
The reactions proceeded efficiently at room temperature, and various
functional groups were well tolerated. The obtained furo[2,3-e][1,4]diazepin-3(2H)-ones
containing a 7-membered dinitrogen-fused ring might be of biological
and medicinal value. The products could be further derived using convenient
procedures.
Reported herein is a novel [5 + 1] cycloaddition− aromatization of benzotriazoles and sulfur ylides to efficiently construct 1,2,4-benzotriazine derivates with good yield. This new protocol does not employ any transition metal reagent and enables the cycloaddition by cleavage of the N−N single bond. The use of inexpensive and readily available starting materials, a broad substrate scope, mild reaction conditions, metal-free, and versatile functionalization of the 1,2,4-benzotriazines make this strategy more attractive.
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