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Background and objectives: Colorectal cancer (CRC) is a disease that begins exclusively in the colon or rectum and is caused by the abnormal growth of glandular epithelial cells within the colon. Homocysteine, vitamin B6, and vitamin D are recognized to play a significant role in colorectal tumor pathogenesis. The aim of this study to investigate serum levels of Hcy, vitamin D and vitamin B6 in colorectal cancer. Methods: The current study investigated the vital roles of homocysteine, vitamin B6 and vitamin D in cancer development by comparing serum levels of colorectal cancer patients with those of the healthy control group at Nanakaly hospital. The levels of serum homocysteine (Hcy), vitamin B6 and vitamin D in 50 colorectal cancer patients and 50 from the healthy control group have been examined. Results: The result shows significantly high values of serum homocysteine (p<0.0001) and significant decreases in values of vitamin B6 and vitamin D (p<0.0001and 0.0010) respectively, in patients with CRC when compared with the healthy group. Conclusions: Our findings demonstrate that increased levels of homocysteine and decreased levels of vitamin B6 and vitamin D could be associated with the pathogenesis and progression of colorectal cancer.

Back ground:-Rheumatoid arthritis (RA) is a systemic disease characterized by progressive, erosive  and chronic poly arthritis, where cellular proliferation of the synoviocytes and neo-angiogenesis leads to formation of pannus which destroys the articular cartilage and the bone . Objective :-to evaluate theOxidative Stress index( OSI )by measuring malondialdehide( MDA) and Total Antioxidant Capacity( TAC) in serum of RA patients in addition to uric acid and albumin and to investigate the alteration in these parameters compared to healthy individuals. Patients and Methods :- twenty five patients with rheumatoid arithritis  and twenty five apparently healthy subjects matched for age and weight have been included in this study,uricacid       and Serum malondialdehyde were measured  by enzymatic methods. serum total  antioxidant capacity was measured according to Miller et al method.              Results  :-The data obtained showed that the  serum levels of Albumin, the total antioxidant capacity were significantly lower in patients with RA than in healthy controls.While the  serum levels of MDA,uric acid were significantly higher in patients with RA than in healthy controls. Conclusion:-  there is acontribution of antioxidant to the pathogenesis of RA.

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