Background: Diabetes Mellitus (DM) is an endocrine disorder due to improper secretion of insulin or action of insulin regardless of hyperglycemia in the body. Reactive oxygen species (ROS) play a major role in the development of insulin resistance and DM.
The harmonious biochemical processes in a healthy individual are due to the balance between essential molecules that are
necessary for the maintenance of physiology of the living system. These include energy bio-molecules, co-factors for
oxidation to attain energy expenditure, regulatory hormones, and protective immune system. Objectives: Identifying predictive factors for
2DM will be benecial to developing effective prevention and early detection of the disease. Therefore, the novelty of this study is to evaluate
whether inammatory markers are different in individuals with versus without T2DM. To assess the effect of glucose, insulin, Homeostasis
metabolic assessment-estimated insulin resistance (HOMA-IR), lipids on cytokine variables in type 2DM subjects. Materials& Methods: Two
hundred and thirty individuals are recruited in to this present study after the approval from Institutional ethical committee for the present study.
The study was conducted in the Department of Biochemistry, Malwanchal university, Indore, India. Age & sex matched one hundred and fteen
human non-2DM individuals were taken into healthy control group. One hundred and fteen subjects, on treatment for 2DM were included in
second group.Results: On comparison of age, Tc, and Ldl parameters between 2DM and control group subjects showed insignicant
differences, whereas parameters of FBS (t=12.24; df=228; P<0.001) HbA1c (t=16.40; df=228; P<0.05) and insulin mean levels (t=2.70;
df=228; P<0.05) showed a signicant difference. Decrease in the levels of serum IL-4 was observed in 2DM subjects when compared with
healthy control subjects. On the contrary, we observed increase in the values of IL-5 and IL-13 in 2DM subjects when compared with healthy
control subjects. In case of IL-10 and IL-12 values, we observed no signicance when compared between the group subjects. Conclusion: The
present study concludes that there is association of IL-4, IL-5 and IL-13 with relation to 2DM. These cytokines can be used as biomarkers for
early identication and diagnosis of secondary complications in 2DM individuals.
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