Evaluation of zinc, copper and oxidative stress in HIV seropositive cases

Doddigarla, Zephy; Bhaskar, Manish Kumar; Lingidi, Jhansi Lakshmi; Ashraf, Raghib

doi:10.1016/j.hivar.2013.07.006

Cited by 3 publications

(3 citation statements)

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“…AIDS infection can be associated with OS. [3][4][5][6][7] AZT is one of the most common drugs used in the treatment of AIDS (40); however, AZT can present a prooxidant activity. Accordingly, AZT has been reported to increase ROS and MDA formation in mouse cardiac mitochondria, macrophages, and endothelial cells.…”

Section: Discussionmentioning

confidence: 99%

“…Acquired immunodeficiency syndrome (AIDS) is a worldwide known disease characterized by progressive depletion of the CD4C helper/inducer subset of T lymphocytes, which leads to severe impairment of immune function. 1,2 In addition, AIDS can be associated with depletion of antioxidant system and an increase in the oxidative stress (OS), [3][4][5][6][7] which is defined as an imbalance of oxidants and antioxidants in favor of the oxidants. [8][9][10][11][12] Another factor that can contribute to the progression of OS is a decrease in total body content of selenium (Se) in HIV patients.…”

Section: Introductionmentioning

confidence: 99%

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The potential toxicological insights about the anti-HIV drug azidothymidine-derived monoselenides in human leukocytes: Toxicological insights of new selenium-azidothymidine analogs

et al. 2016

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Acquired immunodeficiency syndrome (AIDS) is a worldwide disease characterized by impairments of immune function. AIDS can be associated with oxidative stress (OS) that can be linked to selenium (Se) deficiency. Se is fundamental for the synthesis of selenoproteins, such as glutathione peroxidase and thioredoxin reductase. These enzymes catalyze the decomposition of reactive oxygen species and contribute to maintain equilibrium in cell redox status. Literature data indicate that organoselenium compounds, such as ebselen and diphenyl diselenide, have antioxidant properties in vitro and in vivo models associated with OS. Nevertheless, selenocompounds can also react and oxidize thiols groups, inducing toxicity in mammals. Here, we tested the potential cytotoxic and genotoxic properties of six analogs of the prototypal anti-HIV drug azidothymidine (AZT) containing Se (5′-Se-(phenyl)zidovudine; 5′-Se-(1,3,5-trimethylphenyl)zidovudine; 5′-Se-(1-naphtyl)zidovudine; 5′-Se-(4-chlorophenyl)zidovudine) (C4); 5′-Se-(4-methylphenyl)zidovudine (C5); and 5′-(4-methylbenzoselenoate)zidovudine). C5 increased the rate of dithiothreitol oxidation (thiol oxidase activity) and C2-C4 and C6 (at 100 µM) increased DNA damage index (DI) in human leukocytes. Moreover, C5 (200 µM) decreased human leukocyte viability to about 50%. Taken together, these results indicated the low in vitro toxicity in human leukocytes of some Se-containing analogs of AZT.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The potential toxicological insights about the anti-HIV drug azidothymidine-derived monoselenides in human leukocytes: Toxicological insights of new selenium-azidothymidine analogs

et al. 2016

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“…These are important micronutrients involved in functional immune reconstitution. Their deficiency would therefore contribute to the worsening of the quantitative and qualitative deficit immunity [17][18][19][20][21][22][23].…”

Section: Immunologic and Clinical Characteristicsmentioning

confidence: 99%

Skin Diseases in Human Immunodeficiency Virus infected children in the era of Highly Active Antiretroviral Therapy: Epidemiological and Clinical Profile in Pediatric Department of Cotonou, Benin

2017

J Clin Investig Dermatol

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Unlike developed countries, most studies in low-income countries have shown an increase in morbidity and mortality, including dermatological manifestations, during the first two years of Anti Retroviral Therapy (ART) especially during the first 6 months. The causes of this phenomenon are often entangled. The main ones are: Advanced immuno-depression at the time of treatment, SRI, severe malnutrition, difficulties in accessing ARVs and poor adherence or ineffective ARVs [1,3,6].Since the introduction of HAART in developing countries, data on changing the profile of dermatoses in children are almost nonexistent. Therefore in our African context it was appropriate to carry out a study to determine the epidemiological and clinical profile of dermatoses in HIV-infected children, followed in the Pediatrics Department at the University Hospital of Cotonou, Benin. MethodsWe carried out a transversal and descriptive study over 6 months from February to July 2016 in Pediatrics and Medical Genetics Department at the University Hospital of Cotonou (CNHU-C). It covered the group of children aged 6 weeks to 15 years, HIV-infected 9 under or without ART followed since 2002 (year of introduction of ART multi-therapies in the department) as well as the new patients consulted during the period of study. It also included patients whose diagnosis revealed at least one dermatosis. Infants considered HIVinfected were children whose HIV serum was positive after 18 months and those who had a positive Polymerase Chain Reaction (PCR) before 18 months.Children were included after written consent from their parents. Data were based on medical records; interrogation and the physical examination were collected using a fact sheet. The variables studied were qualitative and quantitative.

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