The effect of aqueous garlic extract on the growth of different medically important dermatophytes was studied. The extract proved to have an inhibitory effect on the growth of Microsporum gypseum, Trichophyton verrucosum, Trichophyton violaceum, Trichophyton rubrum, Trichophyton schoenleini, Trichophyton mentagrophytes and Epidermophyton floccosum. The inhibitory concentration ranged from 130‐200 mg/1. Experimental infection was induced in guinea pigs and rabbits. Treatment of the produced lesions included topical application or injection of the extract. The topical treatment was very effective, producing complete healing in 14 to 17 days following twice daily application of the extract for one week.

Parakeratosis is characterized not only by the retention of the nucleus in keratinocytes, but is also characterized by a cell of smaller size. The specific print of a disease helps in the diagnosis. The print will change with different stages of a disease.

Background: We report the first association of Papillon-Lefevre syndrome (PLS) with tyrosinase-negativc albinism in two brothers. Also, we studied T-lymphocytes and mononuclear celi activity in them and in two other cases of PLS not associated with albinism.Objective: To recognize clinical and immunological correlation. Methods: Four PLS patients from 3 different families were studied clinically and immunologically. Two brothers (albino) in one family had recurrent infections. The other two patients from two other families had no infection. The patients' healthy parents were also included in the study.Results: A decreased lymphocyte proliferative response to phytohaemaglutinin and in mononuclear cell activities were detected not only in the PLS patients with recurrent pyogenic infection, but also in their healthy parents. Further investigations of these patients showed impaired humoral and cellular immune response. PLS patients with no infection and their parents showed normal immunoiogic parameters.Conclusion: We suggest dividing PLS on clinical and immunological bases into two variants: PLS with pyogenic infections and the other variety without such infection. PLS with pyogenic infections is associated with immunologic dysfunction. Periodontosis could not be explained on an immunological basis.