Corneocytes in Scaly Parakeratotic Diseases

Amer, Mohamed A.; Mostafa, Fawzia Farag; Tosson, Zenab; Nasr, Awatif Nagib

doi:10.1111/j.1365-4362.1996.tb03024.x

Cited by 5 publications

(7 citation statements)

References 5 publications

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“…The equivalent figures for surface area were 1092–1436 and 1183–1772 μm 2 . Human corneocytes have been reported to have diameters measuring between 30 and 50 μm 30,39,40 and a surface area of 800–1200 μm 2 37,38 . In other animal species, mice have a reported corneocyte diameter of 25–30 μm 24 , guinea pig corneocyte surface area ranged from 1034–1415 μm 2 45 and in neonatal rats the corneocyte surface area was determined as 1908 μm 2 44 .…”

Section: Discussionmentioning

confidence: 99%

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A two‐dimensional morphological study of corneocytes from healthy dogs and cats and from dogs with atopic dermatitis

McEwan

Lu²,

Nuttall

2009

Veterinary Dermatology

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The aim of this study was to determine the dimensions of corneocytes collected from healthy dogs and cats, and from dogs suffering from atopic dermatitis. Samples were collected from the inner pinna, lateral thorax and the groin. D-Squame adhesive discs were used to collect corneocytes from the skin surface and image analysis software was used for measurements. Two differently shaped cells were identified in both animal species. The most common cell type was polygonal, often hexagonal or pentagonal and regular while the second type was smaller, elongated and variable in size and shape. The polygonal cells are corneocytes which probably originate from the interfollicular epidermis. The mean diameter and surface area for healthy canine polygonal corneocytes were 38-43.5 microm and 1092-1436 microm(2). The equivalent Figures for cats were 39.6-48.5 microm and 1183-1772 microm(2). Feline polygonal corneocytes were generally larger than those of the dog. Both feline and canine polygonal corneocytes collected from the ear were generally smaller than those from other body sites. Atopic canine polygonal corneocytes collected from the groin were significantly smaller than healthy groin corneocytes. In healthy dogs the mean length, breadth and surface area of elongated cells were 26.6-35.9 microm, 7.6-10.3 microm and 168.6-240.2 microm(2). The equivalent values for cats were 20.0-37.8 microm, 6.8-9.9 microm and 117.6-245.6 microm(2). The exact nature of the elongated cells is not known but they may be cell fragments or folded corneocytes. They were more common in densely haired skin suggesting the hair follicle as their origin.

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Section: Discussionmentioning

confidence: 99%

“…Human corneocytes are extremely flat, very large cells lacking nuclei, 35,36 with a regular pentagonal or hexagonal shape and a surface area of 800–1200 μm 2 37,38 . Their largest diameter measures between 30–50 μm 30,39,40 . For mice the reported corneocyte diameter is smaller at 25–30 μm 24 .…”

Section: Introductionmentioning

confidence: 99%

A two‐dimensional morphological study of corneocytes from healthy dogs and cats and from dogs with atopic dermatitis

McEwan

Lu²,

Nuttall

2009

Veterinary Dermatology

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“…Electron microscopy reveals changes in the epidermis: decreased numbers of tonofilaments and desmosomes, enlarged intercellular spaces, and signs of ultrastructural parakeratosis of the stratum corneum, including lipid‐ like vacuoles, incomplete keratinization, and nuclear remnants 50 , 91 . The corneocytes are fusiform with numerous pits 99 …”

Section: Histopathologic and Laboratory Findingsmentioning

confidence: 99%

Pityriasis rubra pilaris

1999

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“…Aberrant transcripts of UPF1 in psoriasis scales. The skin scales are mostly composed of corneocytes (29); thus, the tissues may have been fragile for RNA sequencing. Five out of ten psoriasis scales from sporadic psoriasis patients were demonstrated to be reliable sources of RNA, as PcR fragments of UPF1 and AREG mRNAs were amplified successfully in these tissues ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Aberrant expression of the UPF1 RNA surveillance gene disturbs keratinocyte homeostasis by stabilizing AREG

Cheng

Shi

et al. 2020

Int J Mol Med

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The up-frameshift suppressor 1 homolog (UPF1) RNA surveillance gene is a core element in the nonsense-mediated RNA decay (NMd) pathway, which impacts a broad spectrum of biological processes in a cell-specific manner. In the present study, the contribution of the NMd pathway to psoriasis lesions and its moderating effects on the biological processes of keratinocytes was reported. Sanger sequencing for skin scales from two patients with psoriasis identified two mRNA mutations (c.2935_2936insA and c.2030-2081del) in the UPF1 gene. The somatic mutants produced truncated UPF1 proteins and perturbed the NMd pathway in cells, leading to the upregulation of NMD substrates. As the most abundant epidermal growth factor receptor ligand in keratinocytes, it was concluded that amphiregulin (AREG) mRNA is a natural NMd substrate, that is dependent on its 3' untranslated region sequence. Perturbed NMD modulated keratinocyte homeostasis in an AREG-dependent but nonidentical manner, which highlighted the unique characteristics of NMD in keratinocytes. By targeting AREG mRNA post-transcriptionally, the UPF1-NMd pathway contributed to an imbalance between proliferation on the one hand, and apoptosis and abnormal differentiation, migration and inflammatory response on the other, in keratinocytes, which indicated a role of the NMd pathway in the full development of keratinocyte-related morbidity and skin diseases.

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Corneocytes in Scaly Parakeratotic Diseases

Abstract: Parakeratosis is characterized not only by the retention of the nucleus in keratinocytes, but is also characterized by a cell of smaller size. The specific print of a disease helps in the diagnosis. The print will change with different stages of a disease.

Cited by 5 publications

References 5 publications

A two‐dimensional morphological study of corneocytes from healthy dogs and cats and from dogs with atopic dermatitis

A two‐dimensional morphological study of corneocytes from healthy dogs and cats and from dogs with atopic dermatitis

Pityriasis rubra pilaris

Aberrant expression of the UPF1 RNA surveillance gene disturbs keratinocyte homeostasis by stabilizing AREG

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