Objective Pilomatrixoma (calcifying epithelioma of Malherbe) is a benign soft tissue tumour arising from dermis or subcutaneous tissue which should be considered in differential diagnosis of preauricular lesions especially when skin fixation is present. Case Report Twenty-three year old male referred to our clinic with complaint of left preauricular swelling over 18 months which enlarged and became painful in the last 2 months. Because the lesion showed signs of infection, surgery was planned after medical therapy was completed. FNAB suggest pleomorphic adenoma as preliminary diagnosis. US or MRI showed no specific feature. Treatment and Prognosis Total excision, superficial parotidectomy with facial nerve sparing was performed after regression of infectious signs. Postoperatively no recurrence was detected. Conclusion Pilomatrixomas are benign tumours but have diagnostic difficulties according to clinical and cytologic findings. This rare lesion should be kept in mind to avoid misdiagnosis as malign parotid tumours, particularly in the presence of skin change.
In this study, we showed the protective effect of IT and IP oxytocin on cisplatin ototoxicity. We suggest oxytocin in cisplatin ototoxicity, especially via IT route even with high-dose cisplatin.
OBJECTIVE:The objective of this study is to investigate the effect of intratympanic alpha lipoic acid (α-LA) on cisplatin-induced ototoxicity by using distortion product otoacoustic emission (DPOAE).
MATERIALS and METHODS:A total of 24 Wistar albino rats were randomly divided into three groups: group 1 received intraperitoneal (IP) saline + intratympanic (IT) saline as a control group for 4 days (n=8), group 2 received IP cisplatin (20 mg/kg) + IT saline (0.1-0.3 mL) for 4 days (n=8), and group 3 received IP cisplatin (20 mg/kg) + IT α-LA (25 mg/mL) for 4 days (n=8). DPOAEs were performed prior to the procedure and at the end of the experiment on day 5.
RESULTS:Statistically significant DPOAE amplitude reductions were found in the group 2 at all frequencies (2-9 kHz) that demonstrate severe cisplatin ototoxicity (p<0.01). IT α-LA injection provided a protective effect against cisplatin-induced ototoxicity at 3.2, 3.8, 4.5, 5.4, 6.3, and 7.6 kHz frequencies (p<0.05).
CONCLUSION:In our study IT α-LA showed a protective effect against cisplatin-induced ototoxicity in a large frequency range.
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