Nephroblastoma, (otherwise known as nephroblastoma) a second most common malignant neoplasm in childhood has been reported in twins, siblings & successive generations. We report two cases of Wilms tumor in female and male siblings first noticed in each at 14 months of age. No congenital anomalies were observed in these patients. Both patients were treated with surgery & histopathology of both the specimens showed a well differentiated Wilms tumor with favourable histology. On follow up both the patients are alive and in complete remission, 4 years after the diagnosis in female & 6 months after the diagnosis in the male sibling.
Background: The salivary glands are the site of origin of a variety of neoplasm and are also relatively uncommon accounting for <1% of all tumors. Histopathological examination/study plays a major role in the diagnosis of these neoplasms. The aim of the study is to recognize various histomorphological patterns of salivary gland lesions, their frequency, age, gender and site wise distribution Materials and Methods: this study was conducted for two years (Nov 2018-Nov 2020) in the department of pathology KBNIMS, kalaburagi. Total number of salivary gland lesions included were 50. Specimens were processed and stained by hematoxylin and eosin stain followed by microscopic examination. Results: out of total 50 cases 54% were non neoplastic and 46% were neoplastic. Predominantly salivary gland lesions were found in the 3rd-4th decade. Male predominance was seen in all salivary gland lesions. In non neoplastic lesions chronic sialadenitis was predominant (32%) followed by mucocele (10%). In neoplastic lesions, Pleomorphic adenoma was commonest benign tumor accounting for 22%. Mucoepidermoid carcinoma was most common malignant salivary gland tumor. Most of the salivary gland lesions were found in the submandibular gland. Conclusion: Histopathological examination remains gold standard because of their varied histomorphological features
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