Study of Various Histopathological Patterns in Turp Specimens and Incidental Detection of Carcinoma Prostate

Begum, Zeenath; Attar, Abdul Hakeem; Tengli, Mandakini B.; Ahmed, Mohammed Mateen

doi:10.5958/2394-6792.2015.00032.0

Cited by 10 publications

(12 citation statements)

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“…Thapa N et al and Begum Z et al also evaluated only TURP specimens in their respective studies. 12,13 Thapa N et al in their study found 92.2% cases were of BPH, 4.8% were prostatic cancers and these observations were comparable with our findings. 12 Begum Z et al also observed almost similar percentage of BPH and adenocarcinoma cases constituting 96% and 4% respectively.…”

Section: Discussionsupporting

confidence: 82%

“…Five of these cases had poorly differentiated adenocarcinoma with Gleason's score of more than 7 while 3 cases had moderately differentiated adenocarcinoma with Gleason's score of 7. Comparable results were reported by Thapa N et al and Begum Z et al 12,13 …”

Section: Discussionsupporting

confidence: 77%

“…12 Begum Z et al also observed almost similar percentage of BPH and adenocarcinoma cases constituting 96% and 4% respectively. 13 The age of the patients in our study ranged from 39 years to 92 years. Majority of the cases were encountered in the age group of 61-70 years followed by 71-80 years.…”

Section: Discussionmentioning

confidence: 99%

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Histomorphological spectrum of prostatic lesions: a retrospective analysis of transurethral resection of prostate specimens

Sharma

Gandhi

et al. 2017

Int J Res Med Sci

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Background: Prostatic diseases like inflammation, benign prostatic hyperplasia and tumors are important causes of mortality and morbidity in males. The incidence of these lesions increases with advancing age. The second most common cancer among males is prostate cancer, next to lung cancer worldwide. Transurethral resection of prostate (TURP) is most frequently preformed surgical procedure in the clinical practice. The purpose of the study is to evaluate histomorphological spectrum of prostate lesions in TURP specimen with focus on premalignant lesions and incidental carcinomas.Methods: The present study includes 245 cases of TURP specimen from January 2015 to December 2016 received in the post graduate department of pathology, ASCOMS and Hospital. H and E stained sections were examined. The relevant clinical details pertaining to age, clinical complaints and microscopic details were analysed and compared with other similar studies.Results: Of the total 245 TURP specimen, 223 (91.02%) were of nodular hyperplasia, 14 (5.71%) were of prostatic intraepithelial neoplasia and 8 (3.26%) cases were malignant. Benign hyperplasia of prostate (BHP) alone accounted for 91.02% of TURP specimen. Less frequent findings were granulomatous prostatitis in 3.70% and atypical adenomatous hyperplasia (1.22%). All the 8 cases of prostate cancer were incidental carcinoma, 5 of which were poorly differentiated and 3 were moderately differentiated adenocarcinoma.Conclusions: The present study showed that non-neoplastic lesions of prostate are more common than neoplastic ones. The most frequently encountered prostatic lesion was BHP, commonly seen in the age group of 61-70 years. The malignant lesions were common among the males of more than 60 years. TURP can be helpful in early identification of premalignant lesions and incidental prostate cancer which can improve the treatment outcome of patients.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 77%

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Histomorphological spectrum of prostatic lesions: a retrospective analysis of transurethral resection of prostate specimens

Sharma

Gandhi

et al. 2017

Int J Res Med Sci

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“…This finding was in agreement with other studies. 19,20 Incidental carcinoma is carcinoma detected on histo-pathological examination of prostatic tissue which is removed with the clinical diagnosis of benign lesion. In our study 7 out of 8 carcinoma were incidental carcinoma which accounts for 7.29% of all cases.…”

Section: Discussionmentioning

confidence: 99%

Prostatic lesions: Histopathological study in a tertiary care hospital

Bhatta

Hirachan

2018

J. Manmohan Memorial Inst. Health. Sci.

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Background: Prostatic lesions like Nodular hyperplasia of prostate, inflammation and carcinoma are common causes of morbidity and mortality in males. The incidence of these lesions increases with age. This study was conducted with the objective of evaluating histopathological pattern of prostatic lesions.Methods: This was a retrospective study conducted at KIST Medical College from Jan 2014 to Jan 2018. The study included ninety six prostatic specimens received in department of pathology. Hematoxylin and Eosin stained slides were retrieved and reviewed. The specimens and slides were analyzed according to type of specimen, age of patient, histopathological pattern and final diagnosis. Results were analyzed using Statistical Package for Social Science (SPSS, version 21) for Windows. Independent t test was used to correlate the mean age between patients with benign and malignant lesions. P value less than 0.05 was considered as statistically significant.Results: The most common benign lesion was nodular hyperplasia of prostate 86(89.58%). Malignant lesions comprised 8 (8.34%) cases of all prostatic lesions. All the cases of prostate carcinoma were adenocarcinoma. The most frequent Gleason score was 9. Mean age for benign and malignant lesions were 69.6 ± 8.1 years and 72.9 ± 5.2 years respectively. There was no significant difference in the mean age between patients with benign and malignant lesions (p value 0.27).Conclusion: Benign lesions of prostate are more common than malignant lesions. Histopathological examination of prostate specimens have important role in diagnosing various benign and malignant lesions, especially to rule out incidental carcinoma.JMMIHS.2018;4(1):12-19

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“…1,2 The incidence of prostatic lesions increases with increasing age. In the aging male, there is significant tissue remodeling taking place within the prostate.…”

mentioning

confidence: 99%

Study of prostatic pathology and its correlation with prostate specific antigen level

et al. 2017

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Background: Diseases primarily inflicting prostate gland are inflammation, benign prostatic hyperplasia and cancer. Prostate specific antigen is a protein produced by the cells of prostate gland. It has been widely used in the diagnosis and management of patients with prostatic cancer. The aim this study was to determine the correlation between serum prostate specific antigen level and histological findings in biopsy specimens of men with prostatic disease. Materials and Methods: This study was carried out at Kathmandu Medical College and TeachingHospital, department of Pathology over a period of 2 years. One hundred and twenty eight cases with prostatic lesions were included in this study. Prostate specific antigen values of these cases were recorded before the surgical process. Histology of the tissue samples collected after transurethral resection of prostate was studied and relationship with prostate specific antigen level were analyzed.Results: Benign prostatic hyperplasia was the most common histological lesion encountered (n=95; 74.22%). Prostatic adenocarcinomas were seen a decade older than those with benign lesions. Maximum number of the benign cases had the Prostate specific antigen range of 0-7ng/ml. Most of the prostatic intraepithelial neoplasia lesions were seen within the PSA range of 0-7ng/ml and adenocarcinoma in the range of >20ng/ml. Conclusion:Prostate specific antigen is specific for the prostate but not for prostate cancer. Both benign and malignant lesions in prostate can cause increase in serum prostate specific antigen levels, but the chances of malignancy it rising level.

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Study of Various Histopathological Patterns in Turp Specimens and Incidental Detection of Carcinoma Prostate

Cited by 10 publications

References 0 publications

Histomorphological spectrum of prostatic lesions: a retrospective analysis of transurethral resection of prostate specimens

Histomorphological spectrum of prostatic lesions: a retrospective analysis of transurethral resection of prostate specimens

Prostatic lesions: Histopathological study in a tertiary care hospital

Study of prostatic pathology and its correlation with prostate specific antigen level

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