The IPAQ confirmed the high level of physical activity of the study population. Even though the study group was small, the results of ODI showed a minor degree of disability. Med Pr 2018;69(4):365-373
Background. The activity and the role of methylarginine in diabetic patients are subject to continuous research. The mechanism through which diabetes or insulin resistance increases asymmetric dimethylarginine (ADMA) serum levels is not fully understood. Studies indicate increased ADMA serum levels in patients with hypertension, hypercholesterolemia and hyperhomocysteinemia.
A number of epidemiological studies conducted over the last decade indicate a relationship between specific pathogen infections and the development of atherosclerosis, although no pathogenetic pathways connecting these two have been determined. Recent reports support the role of heat shock proteins (HSPs) in atherogenesis. The HSPs are also believed to be a link between the infection and the development of atherosclerotic lesions. The aims of study: Immunohistochemical evaluation of carotid artery segments to show the relationship between the presence of heat shock proteins and the serum levels of anti-hsp60 antibodies. An attempt to demonstrate a relationship between an expression of chronic C. pneumoniae and CMV antigens. Material and Methods: The study included 41 patients qualified for carotid artery endarterectomy and 18 healthy volunteers of corresponding age. Levels of anti-hsp60, anti-C. pneumoniae IgA and IgG, anti-CMV IgG antibodies as well as hsCRP were determined. Results: The mean serum levels of anti-hsp60 antibodies were higher in patients with advanced atherosclerosis as compared to healthy volunteers (55.3±64.1 vs 32.8±29.8; p < 0.05). There was a strong correlation between anti-hsp60 antibodies and the expression of hsp60 in carotid arterial wall, as confirmed by immunohistochemical evaluation. The study group showed statistically significant higher levels of hsCRP. Furthermore, statistically significant higher serum levels of anti-C. pneumoniae IgG and IgA as well as anti-CMV IgG antibodies were found in the study group as compared to controls. No correlation was shown between the markers of chronic infection induced by the tested pathogens and serum levels of anti-HSP and hsCRP. Conclusions: Higher protein expression in vascular walls is closely correlated with the level of anti-hsp60. At the same time, no significant relationship between anti-hsp60 antibodies and serological markers of infection was observed, which may only indicate an indirect role of infection in the assessment of breaking the immunological tolerance against autologous HSPs.
Type 2 diabetes causes a significant risk of cardiovascular diseases, leading to 70% of
deaths in patients with diabetes. The effective treatment of diabetes significantly
reduces the risk of requiring the involvement of specialists from various fields of
medicine. This research aimed to assess the risk of cardiovascular events based on
selected biochemical parameters (glycoprotein [GP] IIb/IIIa, von Willebrand factor [vWf],
fibrinogen) and their changes in response to physical exercise. The research group
consisted of 52 patients with type 2 diabetes with micro- or macro-angiopathy at a mean
age of 63.80 years (8.79). The control group consisted of 50 healthy volunteers (17 women
and 33 men) at a mean age of 51.16 years (6.39). All the patients consented to have their
venous blood tested to measure complete blood counts. Activated GP IIb/IIIa receptors were
labeled and analyzed by flow cytometry. Mean values of vWF factor were higher when
compared with the control group (196.59% [80.32%] vs 148.06% [90.34%], respectively). The
GP IIb/IIIa receptor expression was much higher in test patients than in the control group
(3.91% [2.91%] vs 2.79% [2.51%]). Physical exercise had a positive influence on GP
IIb/IIIa receptor expression and vWF, decreasing their baseline percentage values.
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