Physical activity – related changes in ADMA and vWF levels in patients with type 2 
diabetes – a preliminary study

Fiodorenko-Dumas, Żanna; Dumas, Ilias; Mastej, Krzysztof; Adamiec, Rajmund

doi:10.17219/acem/62663

Cited by 7 publications

(8 citation statements)

References 18 publications

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“…Ring et al [153] reported that a 4-month Nordic walking training was not sufficient to improve vascular function (i.e., aortic pulse wave velocity, aortic augmentation index, arterial stiffness, and reflection index and systemic vascular resistance). In contrast, Fiodorenko-Dumas and colleagues reported a significant reduction in serum levels of von Willebrand factor-a useful marker for endothelial cell efficiency-after 6 weeks of Nordic walking training, likely suggesting a positive influence of such unconventional outdoor activity on vascular function [154]. When considering gym-based activities, Zumba fitness and mini-trampoline rebounding exercise emerged as the most investigated ones [142,144].…”

Section: Exercise As Therapy For Diabetes Mellitus: Unconventional Anmentioning

confidence: 99%

Diabetic Cardiomyopathy and Ischemic Heart Disease: Prevention and Therapy by Exercise and Conditioning

Crisafulli

Pagliaro

Roberto

et al. 2020

IJMS

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Metabolic syndrome, diabetes, and ischemic heart disease are among the leading causes of death and disability in Western countries. Diabetic cardiomyopathy is responsible for the most severe signs and symptoms. An important strategy for reducing the incidence of cardiovascular disease is regular exercise. Remote ischemic conditioning has some similarity with exercise and can be induced by short periods of ischemia and reperfusion of a limb, and it can be performed in people who cannot exercise. There is abundant evidence that exercise is beneficial in diabetes and ischemic heart disease, but there is a need to elucidate the specific cardiovascular effects of emerging and unconventional forms of exercise in people with diabetes. In addition, remote ischemic conditioning may be considered among the options to induce beneficial effects in these patients. The characteristics and interactions of diabetes and ischemic heart disease, and the known effects of exercise and remote ischemic conditioning in the presence of metabolic syndrome and diabetes, are analyzed in this brief review.

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Section: Exercise As Therapy For Diabetes Mellitus: Unconventional Anmentioning

confidence: 99%

Diabetic Cardiomyopathy and Ischemic Heart Disease: Prevention and Therapy by Exercise and Conditioning

Crisafulli

Pagliaro

Roberto

et al. 2020

IJMS

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“…The third part of this study was establishing changes in new water soluble uremic toxins: ADMA, SDMA and TMAO. ADMA is an inhibitor of NO synthase (NOS) and a key enzyme for NO production [52,53,54,55]. SDMA is indirectly inhibiting NOS [13,17,55].…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand increase of ADMA leads to renin-angiotensin-aldosterone system (RAAS) activation [52], decrease in sodium excretion, and increase in blood pressure [53,59], and all these changes could be beneficial during exercise. There were several studies analyzing the influence of exercise on ADMA after few weeks of training in patients with cardiovascular diseases [53,54,55,56,57,62,63,64]. Most of them showed decrease in ADMA level after series of trainings [53,54,55,56,63,64].…”

Section: Discussionmentioning

confidence: 99%

“…There were several studies analyzing the influence of exercise on ADMA after few weeks of training in patients with cardiovascular diseases [53,54,55,56,57,62,63,64]. Most of them showed decrease in ADMA level after series of trainings [53,54,55,56,63,64]. SDMA was analyzed in four studies and its decrease was observed in two studies [53,55].…”

Section: Discussionmentioning

confidence: 99%

“…Most of them showed decrease in ADMA level after series of trainings [53,54,55,56,63,64]. SDMA was analyzed in four studies and its decrease was observed in two studies [53,55]. There were also four studies showing changes in ADMA and SDMA after a single short exercise [17,58,61,65].…”

Section: Discussionmentioning

confidence: 99%

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Changes in Water Soluble Uremic Toxins and Urinary Acute Kidney Injury Biomarkers After 10- and 100-km Runs

Wołyniec

Kasprowicz

Giebułtowicz

et al. 2019

IJERPH

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Acute kidney injury (AKI) is described as a relatively common complication of exercise. In clinical practice the diagnosis of AKI is based on serum creatinine, the level of which is dependent not only on glomerular filtration rate but also on muscle mass and injury. Therefore, the diagnosis of AKI is overestimated after physical exercise. The aim of this study was to determine changes in uremic toxins: creatinine, urea, uric acid, asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), trimethylamine N-oxide (TMAO) and urinary makers of AKI: albumin, neutrophil gelatinase-associated lipocalin (uNGAL), kidney injury molecule-1 and cystatin-C (uCyst-C) after long runs. Sixteen runners, mean age 36.7 ± 8.2 years, (2 women, 14 men) participating in 10- and 100-km races were studied. Blood and urine were taken before and after the races to assess markers of AKI. A statistically significant increase in creatinine, urea, uric acid, SDMA and all studied urinary AKI markers was observed. TMAO and ADMA levels did not change. The changes in studied markers seem to be a physiological reaction, because they were observed almost in every runner. The diagnosis of kidney failure after exercise is challenging. The most valuable novel markers which can help in post-exercise AKI diagnosis are uCyst-C and uNGAL.

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ADMA (asymmetric dimethylarginine) and angiogenic potential in patients with type 2 diabetes and prediabetes

Wieczór

Kulwas

et al. 2020

Exp Biol Med (Maywood)

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Asymmetric dimethylarginine is an endogenous competitive inhibitor of nitric oxide synthase and marker of endothelial dysfunction, but the question remains as to whether asymmetric dimethylarginine is a marker of cardiovascular episodes or their independent risk factor. ADMA/DDAH (dimethylaminohydrolase) pathway regulates vascular endothelial growth factor (VEGF)-mediated angiogenesis due to its impact on the NO formation. The aim of the study was to assess the concentrations of asymmetric dimethylarginine and the angiogenic potential in the blood of subjects with type 2 diabetes (T2DM, n = 33) and patients with prediabetes ( n = 32)—impaired fasting glycemia and/or impaired glucose tolerance (WHO criteria). The study found that both the prediabetes group and subjects with T2DM had significantly elevated concentrations of asymmetric dimethylarginine, significantly high levels of VEGF-A, low ratio of sVEGF-R1/VEGF-A, and sVEGF-R2/VEGF-A. This may suggest endothelial damage at early stages of carbohydrate metabolism dysfunction—before T2DM is diagnosed. Higher proangiogenic potential in prediabetes and T2DM patients than in healthy subjects, is not only the effect of an increase in VEGF-A levels, but also reduced inhibition of circulating receptors. Impact statement Our research provided new insight into the mechanisms governing vascular complications in prediabetes and type 2 diabetes. Unfortunately, most studies focus on angiogenesis markers (VEGF-A, sVEGF-R1, sVEGF-R2) and endothelial dysfunction marker (ADMA) separately. Our findings reported for the first time that endothelial damage and angiogenic potential at early stage of carbohydrate dysfunction appear in prediabetes before type 2 diabetes is diagnosed.

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Physical activity – related changes in ADMA and vWF levels in patients with type 2 diabetes – a preliminary study

Cited by 7 publications

References 18 publications

Diabetic Cardiomyopathy and Ischemic Heart Disease: Prevention and Therapy by Exercise and Conditioning

Diabetic Cardiomyopathy and Ischemic Heart Disease: Prevention and Therapy by Exercise and Conditioning

Changes in Water Soluble Uremic Toxins and Urinary Acute Kidney Injury Biomarkers After 10- and 100-km Runs

ADMA (asymmetric dimethylarginine) and angiogenic potential in patients with type 2 diabetes and prediabetes

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