This study is aimed at knowing the protective role of the aqueous extract of Andrographis paniculata on toxic effects that are induced by butylated hydroxytoluene (BHT) in domestic male rabbits.  The study was conducted in College of Education for Pure Sciences / Univ. of Karbala from the beginning of November 2021 until February 2022. Forty adult male rabbits have been used, which were divided randomly into four equal groups (ten animals per group), the first group(G1) was administered 1ml/kg of corn oil and considered as the control group, the 2nd group (G2) administrated 1mg/kg of BHT, the third group (G3) administrated 100 mg/kg of A. paniculata, while the animals of the fourth group (G4) administrated 1mg/kg of BHT and 100mg/kg of A. paniculata extract orally for a month daily. Fasting Blood samples were collected after the end of experimentation in order to study the concentration of the following parameters: alanine transaminase (ALT), aspartate transaminase (AST), Tumor necrosis factor alpha (TNF-α), alkaline phosphatase (ALP), Cytochrome P450, and Interleukin 6 (IL6) in addition to measurement of the gene expression of CD44

This study is aimed at knowing the protective role of aqueous extract of Andrographis paniculata on the toxic effects induced by butylated hydroxytoluene (BHT) in domestic male rabbits. The study was conducted in College of Education for Pure Sciences / Univ. of Karbala from November 2021 until February 2022. Forty adult male rabbits have been used, which were divided randomly into four equal groups (10animals/group), the first group(G1) was administered with 1ml/kg of corn oil and considered to be the control group. The second group (G2) administrated 1mg/kg of the BHT, the third group (G3) had administrated 100mg/kg of A. paniculata, whereas animals of 4th group (G4) administrated 1mg/kg of the BHT and 100mg/kg of A. paniculata extract orally for a month daily. Fasting Blood samples were collected after the end of the experimentation for the purpose of studying the concentration of the following parameters: Albumin, Urea, Uric acid, superoxide dismutase (SOD), Reduced Glutathione (GSH) and Malondialdehyde (MDA). The results showed that oral administration of BHT caused a significant increase (P<0.01) in concentrations of Urea, Uric acid, and MDA, while there was a significant reduction (P<0.01) in concentration of Albumin and GSH in comparison with the control group.