No abstract

This study is aimed at knowing the protective role of the aqueous extract of Andrographis paniculata on toxic effects that are induced by butylated hydroxytoluene (BHT) in domestic male rabbits.  The study was conducted in College of Education for Pure Sciences / Univ. of Karbala from the beginning of November 2021 until February 2022. Forty adult male rabbits have been used, which were divided randomly into four equal groups (ten animals per group), the first group(G1) was administered 1ml/kg of corn oil and considered as the control group, the 2nd group (G2) administrated 1mg/kg of BHT, the third group (G3) administrated 100 mg/kg of A. paniculata, while the animals of the fourth group (G4) administrated 1mg/kg of BHT and 100mg/kg of A. paniculata extract orally for a month daily. Fasting Blood samples were collected after the end of experimentation in order to study the concentration of the following parameters: alanine transaminase (ALT), aspartate transaminase (AST), Tumor necrosis factor alpha (TNF-α), alkaline phosphatase (ALP), Cytochrome P450, and Interleukin 6 (IL6) in addition to measurement of the gene expression of CD44

This study aimed to know the preventive role of a substance Curcumin .  against damage happening in the nervous system and induced textured monosodium glutamate (MSG) in male rabbits. , sixty of adult male rabbits  were randomly divided into four equal groups (15 animals / group), the first group (G1) intubated with  1 ml / kg ml / kg of corn oil  and served as a control group (G1) . The second group were intubated orally and daily with  3mg /kg of MSG for three months  , while the third group (G3) has intubated orally and daily with  60 mg / kg curcumin for three months, the fourth group intubated orally and daily with 3mg /kg of MSG and  60 mg / kg  of curcumin  for  three months .Fasting blood samples were collected from fasted rabbits at pretreated period , Mid-experiment and at the end of experiment to study the following parameters  : concentration of  Total protein (TP) and Glucose (GLU) in cerebeospinal fluid  . The results revealed that oral dosing with MSG caused  a significant decrease (P <0.01)in concentration of  TP  and significant increase  (P <0.01) in concentration of  GLU compared with the control group. The group that treated with 60mg / kg   curcumin revealed  a significant increase (P <0.01) in   concentration of  TP  while no significant difference was observed in the concentration of GLU  compared with the control group. Experience also shows that oral dosing with MSG and  curcumin caused significant decrease (P <0.01)  in the concentration  TP  ,  and significant increase  in the concentration of  GLU after end of three months compared with the control group .  Histological results from rabbits treated with MSG for three months have showed degenerative changes in spinal cord after staining with H&E  , the  treatment of nervous tissue with Silver stain showed deposit  of beta Amleod Aβ plaques in spinal cord  compared with the control group  while the results showed   the natural structure of spinal cord  by H&E and Silver stain after treatment with curcumin, but for the group that treated with MSG and   curcumin has been observed the natural appearance of the nervous tissue with little appearance of some of the gaps by H & E  with  lack of deposition of Aβ in the spinal cord  by  Silver stain  compared with the control group.     In conclusion , results of this study that   monosodium glutamate (MSG) causes clearly pathological changes in nervous tissue and confirm the protective role of Curcumin against the pernicious influence of the nervous tissue and Some of the ions in the serum of male rabbit

No abstract

The current study aims to know the protective role of the aqueous extract of the Ginkgo biloba against cerebrum damage induced by Aluminum chloride (AlCl3) in male rats. 40 adult male rats were used, which were randomly divided into four equal groups (10 animals/group), the first group (G1)  administered 1 ml/kg of  tap water, the second group (G2) administered 10 mg / kg of AlCl3, the third group (G3) was administered 10 mg/kg of aqueous extract of the Ginkgo biloba ,while the fourth group animals (G4) were administered 10 mg/kg of AlCl3 and 10 mg/kg of Ginkgo biloba aqueous extract orally and daily for 30 days. Fasting blood samples were collected after the end of the experiment to study the following parameters: concentration of soluble acetylcholinesterase AChE(G1), membrane bound acetylcholinesterase AChE (G4), Neuronal Mitochondrial ATPase (Nmit ATPase), Cytochrome C oxidase (COX) , Tumor Necrosis Factor-α (TNF-α). The results showed that oral administration of AlCl3 caused significant increase (P<0.05) in the concentration of AChE (G1), TNF-α, and significant decrease (P<0.05) in the concentration of AChE (G4), Nmit ATPase and COX compared with the control group.