the prevalence of non-communicable diseases is increasing worldwide. Multimorbidity and long-term medical conditions is common among these patients. this study aimed to investigate the patterns of non-communicable disease multimorbidity and their risk factors at the individual and aggregated level. Data was inquired from the nationwide survey performed in 2011, according to the WHO stepwise approach on NCD risk factors. A latent class analysis on multimorbidity components (11 chronic diseases) was performed and the association of some individual and aggregated risk factors (urbanization) with the latent subclasses was accessed using multilevel multinomial logistic regression. Latent class analysis revealed four distinct subclasses of multimorbidity among the iranian population (10069 participants). Musculoskeletal diseases and asthma classes were seen in both genders. In males, the odds of membership in the diabetes class was 41% less by increasing physical activity; but with increased BMI, the odds of membership in the diabetes class was 1.90 times higher. Tobacco smoking increased the odds of membership in the musculoskeletal diseases class, 1.37 and 2.30 times for males and females, respectively. Increased BMI and low education increased the chances of females' membership in all subclasses of multimorbidity. At the province level, with increase in urbanization, the odds of membership in the diabetes class was 1.28 times higher among males (P = 0.027). Increased age, higher BMI, tobacco smoking and low education are the most important risk factors associated with ncD multimorbidity among iranians. interventions and policies should be implemented to control these risk factors.The World Health Organization (WHO) global status report on non-communicable diseases (NCDs) in 2014 reported that NCDs are globally the leading cause of death 1 . In 2016, NCDs killed 287000 people in Iran and the number of NCD related deaths and disability-adjusted life years (DALYs) have increased during the past decades. In just 2016, 6.5 million years of life loss (YLLs), and 8.2 million years of disability (YLDs) were attributed to NCDs in Iran 2 . According to 2017 reports, in the past 20 years, NCD mortality has risen by 14.5%, in Iran; and an adult Iranian's probability of dying prematurely (between 30 and 70 years) from one of the four main NCDs was 17% 3 .A systematic review in WHO Eastern Mediterranean countries in 2013 showed that the high mortality of NCDs is partially related to their multimorbidity 4 . More than half of the adults with NCDs have multimorbidity or multiple concurrent morbid conditions, and not one single chronic disease 5 .The prevalence of multimorbidity is increasing worldwide 6 . NCD multimorbidity affects more young people in low-and middle-income countries. The mean prevalence of multimorbidity was 7.8% in 28 developing open Scientific RepoRtS | (2020) 10:3034 | https://doi.org/10.1038/s41598-020-59668-y www.nature.com/scientificreports www.nature.com/scientificreports/ countries in 2015 7 . NCD multimor...

Lung cancer is the most rapidly increasing malignancy worldwide with an estimated 2.1 million cancer cases in the latest, 2018 World Health Organization (WHO) report. The objective of this study was to investigate the association of air pollution and lung cancer, in Tehran, Iran. Residential area information of the latest registered lung cancer cases that were diagnosed between 2014 and 2016 (N = 1,850) were inquired from the population-based cancer registry of Tehran. Long-term average exposure to PM10, SO2, NO, NO2, NOX, benzene, toluene, ethylbenzene, m-xylene, p-xylene, o-xylene (BTEX), and BTEX in 22 districts of Tehran were estimated using land use regression models. Latent profile analysis (LPA) was used to generate multi-pollutant exposure profiles. Negative binomial regression analysis was used to examine the association between air pollutants and lung cancer incidence. The districts with higher concentrations for all pollutants were mostly in downtown and around the railway station. Districts with a higher concentration for NOx (IRR = 1.05, for each 10 unit increase in air pollutant), benzene (IRR = 3.86), toluene (IRR = 1.50), ethylbenzene (IRR = 5.16), p-xylene (IRR = 9.41), o-xylene (IRR = 7.93), m-xylene (IRR = 2.63) and TBTEX (IRR = 1.21) were significantly associated with higher lung cancer incidence. Districts with a higher multiple air-pollution profile were also associated with more lung cancer incidence (IRR = 1.01). Our study shows a positive association between air pollution and lung cancer incidence. This association was stronger for, respectively, p-xylene, o-xylene, ethylbenzene, benzene, m-xylene and toluene.

Urbanisation et facteurs de risque de maladies non transmissibles (MNT) : approche STEPwise de l'OMS pour la surveillance des facteurs de risque de MNT en République islamique d'Iran en 2011RÉSUMÉ La présente étude a été menée afin d'examiner la relation entre l'urbanisation et les facteurs de risque de MNT, selon le modèle de l'approche STEPwise de l'OMS pour la surveillance des maladies non transmissibles. L'étude s'inscrit dans la surveillance des facteurs de risque de MNT opérée sur 10 069 personnes âgées de plus de 20 ans dans l'ensemble des provinces de la République islamique d'Iran en 2011. À l'aide de données du recensement de 2011, les niveaux d'urbanisation ont pu être déterminés pour toutes les provinces, et la régression logistique a été utilisée afin d'examiner la relation entre l'urbanisation et les facteurs de risque. Parmi les hommes, l'urbanisation avait une corrélation positive avec une faible activité physique (OR = 1,7, IC à 95 % : 1,42-2,09), une . By utilizing 2011 census data, urbanization levels were determined in all provinces and logistics regression was used to examine the relationship between urbanization and risk factors. Among males, urbanization had a positive correlation with low physical activity (OR=1.7; 95% CI: 1.42-2.09), low fruit and vegetable consumption (OR=1.8; 95% CI: 1.09-2.96), and high BMI (OR=1.4; 95% CI: 1.20-1.70). Among females there was a positive and significant correlation with low physical activity (OR=1.2; 95% CI: 1.08-1.49), low fruit and vegetable consumption (OR=1.22; 95% CI: 0.78-1.91) and high BMI (OR=1.3; 95% CI: 1.14-1.53). Thus, urbanization has a significant correlation with increases in NCD factors in the Islamic Republic of Iran.

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