Background: Crohn's disease is a chronic and recurrent inflammatory bowel disease that progresses slowly. Also CD patients have a large number of extra-intestinal manifestations.
Objective: we sought to define the possible associations between inflammatory pathology and localization and on the other hand, inflammatory pathologies and the disease behavior
Methods: A retrospective analytical study was carried out at the level of gastric and general surgery services of Western Algerian University Hospital of Sidi Bel Abbes region, during the period 2007-2019.
Results Our study was based on a total sample of 295 cases involving 114 females (38.6%) and 181 males (61.4%) with a sex ratio of (1.58). The location of the disease at the time of diagnosis was dominated by the ileo-caecal location (55.3%), of which 64.4% were associated with inflammatory pathology (IP). The majority of patients diagnosed with Crohn's disease had an inflammatory behavior and this for all age groups. The appendix, the ulcer and inflammatory anemia are most associated with Crohn’s disease. For inflammatory extra-intestinal manifestations, only group of patients with arthralgia had significantly higher rates in the 20-60 age groups. The mainly noted risk factors were appendectomy with (17.3%), smoking (22.4%) with a highly significant association, and alcoholism (6.1%).
Conclusion According to our results the association of inflammatory pathology and crohn disease is more frequent in male and dominated by arthralgia as extra-intestinal manifestations lesions.
Keywords: Crohn disease; Inflammatory pathology; disease behavior; inflammatory extra-intestinal manifestation.
Background: This study aimed to demonstrate the gender and age-at-onset differences in rheumatoid arthritis (RA) in the western Algerian population and their impacts on patients' clinical features and medical management. Methods: A retrospective cross-sectional study was carried out at the Internal Medicine and Functional Rehabilitation Departments (University Hospital of Sidi-bel-Abbes region) based on medical records of over 306 RA patients diagnosed between 2016 and 2019 according to ACR 1987 criteria. Late-onset RA (LORA) was defined as disease onset at 51 years of age or older. All data were processed and analyzed via SPSS 22.0. Results: We enrolled 306 rheumatoid arthritis patients (85% women) with a mean age-at-onset of 52.47 ± 12.14. Algerian RA women were more at risk of developing type 2 diabetes (P = 0.035), hypertension (P = 0.003), and thyroid disorders (P = 0.05). We did not find any significant relationship between clinical features, laboratory data, and gender. The LORA group comprised 60.5% of our study population with a higher number of comorbidities such as hypertension (P < 0.001), osteoporosis (P = 0.007), and scleroderma (P = 0.014). Nonetheless, we found evidence of an association between positive anti-CCP, RF rate, and age-at-onset (P = 0.001 and P < 0.001, respectively). Conclusions: Algerian RA women with LORA presented a higher prevalence of comorbidities, while Young-onset RA (YORA) was associated with a high rate of RF.
Coexistence of rheumatoid arthritis and gout is considered as rare however some patients may gather both diseases. Long-term treatment with Methotrexate may cause pulmonary pathology. We report a case of a 48-year-old Algerian woman with medical history (swelling of knee and joint pain in the shoulders and hands) diagnosed with Rheumatoid Arthritis (RA), after 3 years of self-medication with Methotrexate; she returned with hyperurecimia that confirmed the co-presence of the gout and RA as well as a pneumonia confirmed with clinical sign and chest X-Ray. Methotrexate dose compliance can reduce adverse effects.
Keywords: Rheumatoid arthritis; Gout; Pneumonia; Methotrexate; Toxicity.
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