Objectives: The aim of this study was to demonstrate the relationships between anti-citrullinated peptide/protein antibodies status and clinical characteristics, disease severity, radiological damages and laboratory assessment in Algerian patients with Rheumatoid arthritis, as well as their importance like a predictive factor for the diagnosis of Rheumatoid arthritis (RA). Methods: 281 patients diagnosed with RA according to ACR 1987 criteria in the  internal medicine and Functional Rehabilitation departments (the University Hospital of Sidi Bel Abbes) were enrolled in the study based on medical records including age, gender, disease duration, disease activity score (DAS28), joint damages, laboratory tests and treatment. All data were processed and analyzed via SPSS 22.0. Results: 86.5% of patients were females with a mean age and disease duration of respectively 52.665±12.3477, 4.19±4.050.  Patients with Anti-CCP positive (79.7%) presented a high disease activity (p<0.0001), a long disease duration (p=0.016) and a erosion damages (p<0.0001). we did not found any significant relation between gender, hands damages and CRP..A logistic regression showed that the presence of Anti-CCP was associated with Erosion, disease activity, age and RF presence. Conclusion: There was a strong relation between Anti-CCP antibodies status and the development of RA in Algerian patients. It could be considered as a useful predictor of disease severity.

Objectives: To determine the epidemiological, clinical, histological, serological and therapeutic profile of celiac disease in children in Western Algeria region.Methods: 250 patients over a period of three years (2016 - 2019) from the pediatric department of the University Hospital of Oran (West Algeria) were included in our retrospective study.Results: We noticed a female predominance with a sex ratio F/M = 1.57. Symptoms were defined by typical (73.2%) and atypical (26.8%) forms, digestive disorders (47.2%), extra digestive disorders (14.4%). Anemia was noted at 73.6%, and the association with autoimmune diseases at 14.8%. Seropositivity was present in 77.6% of cases and histology revealed partial grade villous atrophy at 54%. We noticed a significant link between the histological grade and the serology (p = 0.001), between age and histological grade (p<10-3), between bone age and body mass index (p = 0.017), between the age of onset of the disease and the age of food diversification (p = 0.030), and with the age of breastfeeding (p = 0.026). In addition, we found an excellent correlation between anti-transglutaminase and anti-endomysium autoantibodies during diagnosis and under diet (p<10-3), and between serology during diagnosis and serology under diet (p = 0.002)Conclusion: Celiac disease (CD) of children in western Algeria is characterized by a variety of clinical symptoms. The gluten-free diet remains the only therapy for these affected children. Keywords: celiac disease, children, epidemiology, serology, histology, associated diseases, treatment.

Introduction: Cancer of the stomach is a serious public health issue due to its frequency and severity. It is one of the most common causes of cancer-related death for both sexes and is a major contributor to the global burden of disease. To better understand the epidemiological, clinical, and pathological characteristics of gastric cancer in the Western Algerian region Sidi Bel Abbes, our study aimed to investigate the prevalence, risk factors, and clinical outcomes of gastric cancer in this region.Methods: The medical records of 131 patients with gastric cancer in the Sidi Bel Abbes region between January 2015 and December 2019 were reviewed retrospectively in order to gain insight into the epidemiology of gastric cancer in the region.Result: The results of this statistical analysis indicate that there is a male predominance in the cases studied and that the average age of the patients is 61.069 years. Histologically, carcinoma is the most common histological type (87.7%). 77.1% of cases were diagnosed in stages III and IV of TNM, and 46.6% of cases were found in the pyloric antrum. 38.2% of the cases had atrophic chronic gastritis as a precancerous lesion, and 16.8% had acute or chronic gastritis. Conclusion:The diagnosis of gastric cancer is often made at a late stage with a poor prognosis. However, in order to develop strategies for prevention and early detection, extensive research is still needed to identify the risk factors for gastric cancer.

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