BackgroundFunctional magnetic resonance imaging (fMRI) has been widely used to investigate the brain effect of acupuncture point Stomach 36 (ST36, Zusanli). However, inconsistent results have hindered our understanding of the neural mechanisms of acupuncture at ST36.ObjectiveTo perform a meta-analysis of fMRI studies on acupuncture at ST36 to assess the brain atlas of acupuncture at ST36 from available studies.MethodBased on a preregistered protocol in PROSPERO (CRD42019119553), a large set of databases was searched up to August 9, 2021, without language restrictions. Peak coordinates were extracted from clusters that showed significant signal differences before and after acupuncture treatment. A meta-analysis was performed using seed-based d mapping with permutation of subject images (SDM-PSI), a newly improved meta-analytic method.ResultsA total of 27 studies (27 ST36) were included. This meta-analysis found that ST36 could activate the left cerebellum, the bilateral Rolandic operculum, the right supramarginal gyrus, and the right cerebellum. Functional characterizations showed that acupuncture at ST36 was mainly associated with action and perception.ConclusionOur results provide a brain atlas for acupuncture at ST36, which, besides offering a better understanding of the underlying neural mechanisms, also provides the possibility of future precision therapies.
Background: To explore the brain function regions characteristics of the acupoint combination, this study observed activity changes in the brain regions of healthy volunteers after acupuncture at both Taixi (KI3) and Taichong (LR3) (KI3 + LR3) and KI3 alone using resting-state functional magnetic resonance imaging (fMRI). Methods and Materials: 30 healthy volunteers were randomly allocated into two groups, one group received acupuncture at KI3 and LR3, the other only acupuncture at KI3, 15 cases in each group. All volunteers underwent resting-state fMRI of the brain 15 minutes before acupuncture, and which the needle was retained in place for 30 minutes; 15 minutes after withdrawing the needle underwent a further session of resting-state fMRI. The amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) were used to analyze the changes in brain regions. Results: The KI3+LR3 group compared with the KI3 group, the ALFF analysis indicated that the brain changes relatively concentrated in BA 2, 3, 7, 8, 9, 10, 18, 19, 20, 31, 32, 40, 46 and the cerebellum posterior lobe, the ReHo analysis indicated that the brain changes relatively concentrated in BA 4, 6, 7, 10, 11, 18, 19, 20, 21, 22, 31, 40 and the cerebellum posterior lobe. Conclusion: Based on this study, compared with acupuncture at KI3, acupuncture at KI3 + LR3 which could specifically influence BA 7, 10, 18, 19, 20, 31, 40 and cerebellum posterior lobe, which may be related to synergy mechanism of two acupoints combination treatment.
Background: To explore the brain function regions characteristics of the acupoint combination, this study observed activity changes in the brain regions of healthy volunteers after acupuncture at both Taixi (KI3) and Taichong (LR3) (KI3 + LR3) and KI3 alone using resting-state functional magnetic resonance imaging(fMRI). Methods: 30 healthy volunteers were randomly allocated into two groups, one group received acupuncture at KI3 and LR3, the other only acupuncture at KI3, 15 cases in each group. All volunteers underwent resting-state fMRI of the brain 15 minutes before acupuncture, and which the needle was retained in place for 30 minutes; 15 minutes after withdrawing the needle underwent a further session of resting-state fMRI. The amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) were used to analyze the changes in brain regions. Results: The KI3+LR3 group compared with the KI3 group, the ALFF analysis indicated that the brain changes relatively concentrated in BA 2, 3, 7, 8, 9, 10, 18, 19, 20, 31, 32, 40, 46 and the cerebellum posterior lobe, the ReHo analysis indicated that the brain changes relatively concentrated in BA 4, 6, 7, 10, 11, 18, 19, 20, 21, 22, 31, 40 and the cerebellum posterior lobe. Conclusion: Based on this study, compared with acupuncture at KI3, acupuncture at KI3 + LR3 which could specifically influence BA 7, 10, 18, 19, 20, 31, 40 and cerebellum posterior lobe, which may be related to synergy mechanism of two acupoints combination treatment.
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