Functional magnetic resonance imaging studies of acupuncture at ST36: a coordinate-based meta-analysis

Abstract

BackgroundFunctional magnetic resonance imaging (fMRI) has been widely used to investigate the brain effect of acupuncture point Stomach 36 (ST36, Zusanli). However, inconsistent results have hindered our understanding of the neural mechanisms of acupuncture at ST36.ObjectiveTo perform a meta-analysis of fMRI studies on acupuncture at ST36 to assess the brain atlas of acupuncture at ST36 from available studies.MethodBased on a preregistered protocol in PROSPERO (CRD42019119553), a large set of databases was searched up to August 9, 2021, without language restrictions. Peak coordinates were extracted from clusters that showed significant signal differences before and after acupuncture treatment. A meta-analysis was performed using seed-based d mapping with permutation of subject images (SDM-PSI), a newly improved meta-analytic method.ResultsA total of 27 studies (27 ST36) were included. This meta-analysis found that ST36 could activate the left cerebellum, the bilateral Rolandic operculum, the right supramarginal gyrus, and the right cerebellum. Functional characterizations showed that acupuncture at ST36 was mainly associated with action and perception.ConclusionOur results provide a brain atlas for acupuncture at ST36, which, besides offering a better understanding of the underlying neural mechanisms, also provides the possibility of future precision therapies.

Electroacupuncture modulates abnormal brain connectivity after ischemia reperfusion injury in rats: A graph theory‐based approach

“…The previous brain imaging research has proven that the functional whole‐brain network architecture of healthy individuals is altered after EA intervention, which confirms the brain function related to the specificity of meridians and acupoints (Han, Jin, et al., 2020). A meta‐analysis study with ST36 showed that it was able to activate the left cerebellum, the bilateral Rolandic operculum, the right supramarginal gyrus, and the right cerebellum, and acupuncture at ST36 was primarily associated with perception and action according to functional characterizations (Zhang et al., 2023).…”