A synthesis of (1-phenyltetrazol-5-ylthio)acetic acid derivatives has been developed. Functional variations concern the carboxylic group and/or the 4 position of phenyl group. Most of the compounds prepared have been tested with regard to their antimycobacterial activity but the activities found are medium or low ones. However, (1-phenyltetrazol-5-ylthio)acetic acid is better than the antituberculotic isoniazid in the activity to Mycobacterium avium.
Some N-acylthioamides, thiobenzoylthioureas, and thiobenzoylureas were synthesized. The substances prepared were tested for their in vitro antimycobacterial activity. The structure of thiobenzoylureas was studied by synthetic and spectral methods.
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