Acylated thioamides and related compounds as potential antituberculotics

Abstract

Some N-acylthioamides, thiobenzoylthioureas, and thiobenzoylureas were synthesized. The substances prepared were tested for their in vitro antimycobacterial activity. The structure of thiobenzoylureas was studied by synthetic and spectral methods.

Reactions of 5‐methylene‐1,3‐thiazolidine‐2‐thione and 5‐methylene‐2‐oxazolidinone with isocyanates catalyzed by bases

“…A subsequent acylation of 1 with an acyl chloride could be carried out under basic conditions [5]. Recently, acylated thioamides (4) and related compounds have been shown to be potential antituberculotics [6]. In our reaction system, we have found that, by use of a catalytic amount of a very common tertial amine as a base, compounds 4 can be easily synthesized from the reaction of 1 with isocyanates.…”

Synthesis and Insecticidal Activity of Heterocyclic Carbothioamides against Sogatodes orizicola

“…However, little attention has been given to the corresponding heterocyclic carbothioamides. Pyridinyl and pyrazinyl carbothioamides have been reported as antituberculotics (Mollin et al, 1988), quinolinyl carbothioamides have been reported as plant microbiocides (Kluge et al, 1986), and benzofuranyl, pyridinyl, and furanyl carbothioamides have been reported as antitumor agents (Brouwer and Van Hes, 1986).…”