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The present experiments were carried out on the relationship between triglyceride synthesis and fatty acid oxidation in liver of chicks treated by estrogen, in order to study on the mechanism underlying estrogen-induced hypertriglyceridemia. Estrogen treatment increased the incorporation of 14C-acetate into fatty acid and of 14C-palmitate into triglyceride in vivo and in vitro. This result suggests that triglyceride synthesis is stimulated by estrogen.The 14C incorporation from [1-14C] palmitate into CO2 in vivo and in vitro was decreased by estrogen treatment, whereas that from [1-14C] acetate into CO2 in vitro was increased.This result suggests that fatty acid oxidation is suppressed by estrogen.The results described above suggest that the combination of increased rate of triglyceride synthesis and decreased rate of fatty acid oxidation in liver may, at least in part, contribute to estrogen-induced hypertriglyceridemia. The specific activities of all the hepatic lipogenic enzymes examined were increased by estrogen treatment.Jpm. J. Zootech. Sci., 53 (10): [699][700][701][702][703][704][705][706] 1982

Triglyceride synthesis and fatty acid oxidation in chick adipose tissue were studied by measuring the incorporation of [1-14C] acetate or [1-14C] palmitate into triglyceride and CO2 in vivo and in vitro in order to investigate the effect of estrogen on adipose tissue accumulation in chicks. Estrogen treatment increased the incorporation of 14C-acetate into total fatty acid and of 14C -palmitate into triglyceride . This result suggests that de novo triglyceride synthesis is stimulated by estrogen. Incorporation of 14C-palmitate into CO2 was increased by estrogen treatment, whereas that of 14C-acetate into CO2 was decreased. This result suggests that fatty acid oxidation is also stimulated by Jpn. J. Zootech. Sci., 51 (9): [673][674][675][676][677][678][679] 1980

Triglyceride synthesis and fatty acid oxidation in the chick adipose tissue were studied by measuring the incorporation of [1-14C] acetate or [1-14C] palmitate into triglycerides

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