The presence of blood-brain barrier (BBB) that limits effective penetration of therapeutics is the main reason for poor outcomes of glioblastoma (GBM) treatment. Ultrasound (US) combined with microbubbles (MBs) can precisely disrupt the tight junctions of brain endothelial cells, thus creating "acoustic pores" and non-invasive opening the BBB. Here, chitosan oligosaccharide (COS) is conjugated with a sonosensitizer protoporphyrin IX (PpIX) and an immune-enhancing adjuvant Poly(I:C) via electrostatic adsorption, and crosslinked with a tumor-targeting molecule hyaluronic acid (HA) affording nanosonosensitizers HA-Poly(I:C)/COS-PpIX (abbreviated as "HP/CP" NSs). HP/ CP NSs can target and penetrate GBMs, and trigger reactive oxygen species production upon US, simultaneously causing mitochondrial dysfunction and DNA damage. Tumor-associated antigens released by sonodynamic therapyinduced immunogenic cell death and loaded Poly(I:C) form an in situ vaccine together to potentiate antitumor immune responses. In orthotopic GBM mice models, the HP/CP+US treatments prolong mice survival, enhance cytotoxic T-lymphocytes infiltration, and activate peripheral immune circulation. Besides, HP/CP NSs possess favorable biosafety profiles. Collectively, this study sheds light on the application of HP/CP NSs for synergistic sonoimmunotherapy of GBMs after non-invasive opening of the BBB.
The blood-brain barrier (BBB) is a major limiting factor that prevents the treatment of Parkinson's disease (PD). In the present study, MgOp@PPLP nanoparticles are explored by using MgO nanoparticles as a substrate, polydopamine as a shell, wrapping anti-SNCA plasmid inside, and modifying polyethylene glycol, lactoferrin, and puerarin on the surface to improve the hydrophilicity, brain targeting and antioxidant properties of the particles, respectively. MgOp@PPLP exhibits superior near-infrared radiation (NIR) response. Under the guidance of photothermal effect, these MgOp@PPLP particles are capable of penetrating the BBB and be taken up by neuronal cells to exert gene therapy and antioxidant therapy. In both in vivo and in vitro models of PD, MgOp@PPLP exhibits good neuroprotective effects. Therefore, combined with noninvasive NIR radiation, MgOp@PPLP nanoplatform with good biocompatibility becomes an ideal material to combat neurodegenerative diseases.
Parkinson's Disease
In article 2201655, Yan‐Qing Guan and co‐workers successfully develop a novel photo‐controlled drug delivery system for the treatment of Parkinson's disease. This nanoparticle uses MgO nanoparticles as a substrate, polydopamine as a shell and carries anti‐SNCA plasmid and puerarin. Under the irradiation of 808 nm near‐infrared light, the composite nanoparticles in deep tissues are activated, then absorbed by nerve cells after penetrating the blood–brain barrier, playing the role of antioxidation, anti‐inflammation and inhibiting the accumulation of α‐synuclein. Therefore, this strategy for intracerebral drug delivery can be an ideal approach to combat neurodegenerative diseases.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.