NIR‐Assisted MgO‐Based Polydopamine Nanoparticles for Targeted Treatment of Parkinson's Disease through the Blood–Brain Barrier

Gao, Yifei; Cheng, Yuxue; Chen, Jiapeng; Lin, Danmin; Liu, Chao; Zhang, Lingkun; Yin, Liang; Yang, Runcai; Guan, Yan‐Qing

doi:10.1002/adhm.202201655

Cited by 8 publications

(8 citation statements)

References 56 publications

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“…At the later and final stages of layer formation, a unified structure is reported [77]. In the same manner, PDA can be utilized as an external coating of various NPs as metallic or polymeric NPs and can confer to them enhanced biocompatibility and photothermal conversion properties (Figure 1c) [78][79][80].…”

Section: Synthetic Melanin-like Materialsmentioning

confidence: 98%

Functionalization of and through Melanin: Strategies and Bio-Applications

Mavridi-Printezi

Menichetti

Mordini

et al. 2023

IJMS

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A unique feature of nanoparticles for bio-application is the ease of achieving multi-functionality through covalent and non-covalent functionalization. In this way, multiple therapeutic actions, including chemical, photothermal and photodynamic activity, can be combined with different bio-imaging modalities, such as magnetic resonance, photoacoustic, and fluorescence imaging, in a theragnostic approach. In this context, melanin-related nanomaterials possess unique features since they are intrinsically biocompatible and, due to their optical and electronic properties, are themselves very efficient photothermal agents, efficient antioxidants, and photoacoustic contrast agents. Moreover, these materials present a unique versatility of functionalization, which makes them ideal for the design of multifunctional platforms for nanomedicine integrating new functions such as drug delivery and controlled release, gene therapy, or contrast ability in magnetic resonance and fluorescence imaging. In this review, the most relevant and recent examples of melanin-based multi-functionalized nanosystems are discussed, highlighting the different methods of functionalization and, in particular, distinguishing pre-functionalization and post-functionalization. In the meantime, the properties of melanin coatings employable for the functionalization of a variety of material substrates are also briefly introduced, especially in order to explain the origin of the versatility of melanin functionalization. In the final part, the most relevant critical issues related to melanin functionalization that may arise during the design of multifunctional melanin-like nanoplatforms for nanomedicine and bio-application are listed and discussed.

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Section: Synthetic Melanin-like Materialsmentioning

confidence: 98%

Functionalization of and through Melanin: Strategies and Bio-Applications

Mavridi-Printezi

Menichetti

Mordini

et al. 2023

IJMS

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“…Fortunately, PDA surface modification can effectively improve the biocompatibility of materials without affecting the viability of most mammalian cells. Guan et al evaluated data from mice who were intravenously administered surfacemodified PDA for 1 month and observed no significant organ inflammation or lesions; all blood markers were within normal limits (Gao et al, 2022). These findings indicate that PDA has good biocompatibility and low cytotoxicity.…”

Section: Biocompatibilitymentioning

confidence: 99%

Advances in the study of polydopamine nanotechnology in central nervous system disorders

Ren,

Xiao,

et al. 2024

Front. Mater.

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Disorders of the central nervous system (CNS) constitute a significant global health concern at the moment. Most CNS disorders are characterized by severe neuronal damage with excessive production of reactive oxygen species, which induces high levels of oxidative stress and intense inflammatory responses in the affected tissues, thus aggravating disease pathology. Notably, the blood–brain barrier makes it difficult to deliver many drugs and biologics to the CNS, which creates great difficulties in the diagnosis and treatment of CNS disorders. Recent research on polydopamine nanotechnology has led to the discovery of many promising properties; it shows strong scavenging ability for reactive oxygen species, prevents activation of pro-inflammatory microglia, and its repair function can reduce brain damage and protect neurons. Moreover, polydopamine nanotechnology can improve the blood–brain barrier permeability of biologics and reduce their neurotoxicity. It is therefore a promising candidate in the treatment of CNS disorders associated with oxidative stress. In the present paper, we review the functionality of polydopamine nanotechnology as well as the potential and recent advances of polydopamine-based nanosystems in the diagnosis and treatment of various CNS disorders, including Alzheimer’s disease, Parkinson’s disease, stroke, spinal cord injury, and glioma. Finally, we predict how polydopamine nanoparticles may guide future therapeutic strategies to address CNS disorders such as epilepsy, which currently have no cure.

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“…The released pDNA can silence α-synuclein by suppressing the expression of SNCA (Figure 7C), and protect neurons. 175 Similarly, Gao et al 176 fabricated polydopamine nanoparticles and coated with magnesium oxide and anti-SNCA plasmids. The nanoparticles exhibited brain targeting capability and antioxidative activity, and showed good neuroprotective effect.…”

Section: Gene Therapymentioning

confidence: 99%

Targeting the pathogenesis and boosting the therapeutic efficacy of Parkinson's disease by advanced nanoparticles

Liu

Hua

Zheng

et al. 2023

MedComm – Biomaterials and Applications

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With the aging of global population, the early diagnosis and treatment of neurodegenerative diseases such as Parkinson's disease (PD) have attracted considerable attention. Despite great advances achieved during the past decades, PD as the second largest neurodegenerative disease is still incurable. In the clinical practice, PD patients are mainly treated by drugs, and supplemented with deep brain stimulation or nerve nucleus destruction. The existing drugs can only relieve the symptoms of motor disorder, and cannot stop the progression of PD. Compared with small molecular drugs, nanoparticles exhibit multiple functions in the neuroprotection and neurorepair due to their tunable physical and chemical properties, easy modification and functionalization. Herein, we first briefly review the characteristics of nanoparticles crossing the blood–brain barrier, which is a primary challenge for the treatment of PD. Then, we summarize the pathologic mechanisms of PD and comprehensively discuss the novel PD therapy based on diverse nanoparticles, including alleviating oxidative stress, scavenging α‐synuclein aggregates, chelating metal ions, delivering neurotrophic factors and genes, and transplanting stem cells. This review aims to highlight the great potential of advanced nanoparticles in the therapy of PD.

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NIR‐Assisted MgO‐Based Polydopamine Nanoparticles for Targeted Treatment of Parkinson's Disease through the Blood–Brain Barrier

Cited by 8 publications

References 56 publications

Functionalization of and through Melanin: Strategies and Bio-Applications

Functionalization of and through Melanin: Strategies and Bio-Applications

Advances in the study of polydopamine nanotechnology in central nervous system disorders

Targeting the pathogenesis and boosting the therapeutic efficacy of Parkinson's disease by advanced nanoparticles

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