In the present study, we demonstrated that whether the
gut microbiota
and related metabolites contribute to the therapeutic effect of total
sesquiterpenoids (TSs) from loquat leaves on obesity. A 4-week high
fat diet was used to induce obesity which was then treated with TSs
for another 4 weeks. TSs remarkedly reduced the weight of body and
white adipose and the levels of total cholesterol (TC) and triglyceride
(TG) in serum. We also found that TSs restored the diversity and richness
of gut microbiota. In addition, TSs administration affected the relative
abundance of seven key genera. Meanwhile, TSs were determined to affect
the metabolism of the host through detecting the metabolites in feces.
By applying KEGG and the correlation analysis with gut microbiota,
10 differential metabolites were identified to be the key. The results
in this work proved that TSs inhibited obesity by remodeling gut microbiota
and related metabolites.
We propose a facile and scalable in situ polymerization strategy to selectively introduce the active quinone-based components across the carbon nanotube (CNT) surface. It can be observed that the optimized...
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