A concise synthesis of APDOEGCg (3) was accomplished. Due to the reactivity of its amine group, the compound could be easily converted to the fluorescein probe 21 and immunogen probe 22 efficiently. We then demonstrated the usefulness of the probes for imaging studies and the generation of antibodies.
Activity. -Title compound (IV), a simplified analogue of the naturally occurring epigallocatechingallate, is prepared via direct transformation of the nitroolefin moiety of starting compound (I) to the ketone functionality under reductive conditions using titanium trichloride and the selective construction of the 2,3-cis stereochemistry. Structurally diversified EGCG analogue (IV) shows potent anti-influenza virus activity indicating that the hydroxyl groups on the A-ring are not crucial for activity. -(FURUTA*, T.; HIROOKA, Y.; ABE, A.; SUGATA, Y.; UEDA, M.; MURAKAMI, K.; SUZUKI, T.; TANAKA, K.; KAN, T.; Bioorg. Med. Chem.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.