Concise Synthesis of Dideoxy‐epigallocatechin Gallate (DO‐EGCG) and Evaluation of Its Antiinfluenza Virus Activity.

Abstract

Activity. -Title compound (IV), a simplified analogue of the naturally occurring epigallocatechingallate, is prepared via direct transformation of the nitroolefin moiety of starting compound (I) to the ketone functionality under reductive conditions using titanium trichloride and the selective construction of the 2,3-cis stereochemistry. Structurally diversified EGCG analogue (IV) shows potent anti-influenza virus activity indicating that the hydroxyl groups on the A-ring are not crucial for activity. -(FURUTA*, T.; HIROOKA, Y.; ABE, A.; SUGATA, Y.; UEDA, M.; MURAKAMI, K.; SUZUKI, T.; TANAKA, K.; KAN, T.; Bioorg. Med. Chem.

Tea: A native source of antimicrobial agents

“…Following this report, tea polyphenols have received more attention as an alternative measure against seasonal as well as pandemic influenza. Recently, Furuta et al (2007) synthesized di-deoxy-epigallocatechingallate 3 (Fig. 5), an analog of EGCG that was evaluated for anti-influenza virus activity.…”