In this study, it was aimed to examine the antioxidant and antihepatotoxic effects of hydroxyurea derivative Schiff bases on serum biochemical parameters (AST, ALT, LDH, urea, creatinine and total bilirubin) and antioxidant parameters (SOD, CAT, GPx, MDA). In this study, a total of 49 adult male Wistar rats was examined and they were divided into 7 equal groups. DMSO, which is diluted only with corn oil, was administered to control group. 25 mg / kg ligand, 25 mg / kg Schiff base - manganese, 25 mg / kg Schiff base-copper, 25 mg / kg Schiff base - zinc, 25 mg / kg Schiff base - nickel, 25 mg / kg Schiff base - cobalt complexes were administered to rats of experimental group subcutaneously for 15 days with three-day intervals throughout the test process. All specimens were killed by decapitation and their livers were extracted. According to the results obtained, ALT level was observed to be higher (P<0.05) in the Cu-L group compared to other groups. LDH level was observed to be higher (P<0.05) in the Cu-L and Co-L groups compared to other groups. SOD level was observed to be higher (P<0.05) in the Cu-L, Mn-L and Zn-L groups compared to other groups. MDA level was observed to be higher (P<0.05) in the Ni-L, Cu-L, Zn-L groups compared to other groups. In conclusion, it can be suggested that the determination of the pharmacological characteristics of them can be beneficial in numerous fields of application thanks to the antioxidant and hepatotoxic activities demonstrated by hydroxyurea derivative Schiff bases.
Thiadiazole derivatives and its metal compounds have antibacterial, antifungal, antitumoral, antiproliferative and antioxidant properties. In the study, the effects caused by thiadiazole ligand and its metal complexes upon the fatty acids and lipophilic vitamins in livers of rats were examined. The fatty acids in liver were specified by GC while the lipophilic vitamins were specified by HPLC. It was observed that the amounts of oleic acids (18:1, n-9) and monounsaturated fatty acids (MUFA) notably increased in the Mn complex group while the amounts of arachidonic acid (20:4, n-6) notably increased in the ligand group, compared to control group. The amounts of vitamin K2, vitamin D3 and α-tocopherol considerably increased in all groups compared to control group. It was noted that the amounts of α-tocopherol were elevated in both the Mn and Cr complex groups compared to control group. However, this elevation was matching with the amount in the same groups. Nevertheless, the amount of retinol was determined to be lower in the Mn complex group compared to other groups. Accordingly, it can be considered that thanks to the utilization of toxic metals such as manganese, cadmium and chrome, unsaturated fatty acids influenced the activities of the enzymes in liver tissue, which are in charge of fatty acid chain elongation.
Journal of Cellular Neuroscience and Oxidative Stress is an online journal that publishes original research articles, reviews and short reviews on the molecular basis of biophysical, physiological and pharmacological processes that regulate cellular function, and the control or alteration of these processes by the action of receptors, neurotransmitters, second messengers, cation, anions, drugs or disease. Areas of particular interest are four topics. They are; A-Ion Channels (Na + -K + Channels, Clchannels, Ca 2+ channels, ADP-Ribose and metabolism of NAD + , Patch-Clamp applications) B-Oxidative Stress (Antioxidant vitamins, antioxidant enzymes, metabolism of nitric oxide, oxidative stress, biophysics, biochemistry and physiology of free oxygen radicals) C-Interaction Between Oxidative Stress and Ion Channels in Neuroscience (Effects of the oxidative stress on the activation of the voltage sensitive cation channels, effect of ADP-Ribose and NAD + on activation of the cation channels which are sensitive to voltage, effect of the oxidative stress on activation of the TRP channels, role of TRPM2 channels in neurodegenerative diseases such Parkinson's and Alzheimer's diseases) D-Gene and Oxidative Stress (Gene abnormalities. Interaction between gene and free radicals. Gene anomalies and iron. Role of radiation and cancer on gene polymorphism)
Journal of Cellular Neuroscience and Oxidative Stress is an online journal that publishes original research articles, reviews and short reviews on the molecular basis of biophysical, physiological and pharmacological processes that regulate cellular function, and the control or alteration of these processes by the action of receptors, neurotransmitters, second messengers, cation, anions, drugs or disease. Areas of particular interest are four topics. They are; A-Ion Channels (Na +-K + Channels, Clchannels, Ca 2+ channels, ADP-Ribose and metabolism of NAD + , Patch-Clamp applications) B-Oxidative Stress (Antioxidant vitamins, antioxidant enzymes, metabolism of nitric oxide, oxidative stress, biophysics, biochemistry and physiology of free oxygen radicals) C-Interaction Between Oxidative Stress and Ion Channels in Neuroscience (Effects of the oxidative stress on the activation of the voltage sensitive cation channels, effect of ADP-Ribose and NAD + on activation of the cation channels which are sensitive to voltage, effect of the oxidative stress on activation of the TRP channels in neurodegenerative diseases such Parkinson's and Alzheimer's diseases) D-Gene and Oxidative Stress (Gene abnormalities. Interaction between gene and free radicals. Gene anomalies and iron. Role of radiation and cancer on gene polymorphism)
Objective: In this study, the nutritional parameters such as moisture, ash, crude fiber, crude protein, crude fat, carbohydrate and nutritive value of sage (Salvia officinalis), linden (Tilia platyphyllos), thyme (Thymus vulgaris), daisy (Matricaria chamomilla) and ginger (Zingiber officinale) plants sold in Bingol herbalists and widely used for treatment among the public were determined by analysis. Methods: In 2019, 5 different medicinal plant samples were obtained from 3 different herbalists in Bingöl. Afterwards, the nutritional contents of these plants were analyzed using official Association of Official Analytical Chemists (AOAC) methods and different biochemical methods. Results: Moisture, ash, crude protein, crude fat, crude fiber, carbohydrate percentages and nutritional values (kcal/100g) of the studied plant samples (0.10 % - 5.67, 4.67 - 11.89, 6.59 - 18.22, 2.12 - 6.80, 16.65 - 29.16, 40.18 - 63.68 % and 245.66 kcal - 347.49 kcal), respectively. The moisture contents of sage, linden and daisy samples were determined as 0.85 % to 4.84 % and they were found safe for consumption according to the Herbal Tea Standard of the TS 12933 Turkish Standards Institute, but ash levels exceeding the limit level of thyme samples (10.78-11.89 %) were found to be unsuitable. The moisture content of the thyme and ginger samples (0.10 - 5.67 %) (maximum 12 % for both), as well as the ash content of the thyme samples (maximum 14 %) and ginger (maximum 12 %) all fall within the Turkish Food Codex limit values.While statistically significant differences were observed in moisture, ash, crude fiber, carbohydrate and nutritional value groups (p0.05). The crude protein content of daisy (D2, D3) and linden (L1, L2) samples, the crude fiber content of daisy (D2, D3) and thyme (T1,T2,T3) samples, the carbohydrate content of ginger (G1, G2, G3) and sage (S1, S3) samples were all found to be high. Conclusion: Plants such as Salvia officinalis and Zingiber officinale, which are rich in carbohydrates, crude protein and crude fiber content, are used for medicinal purposes. In addition, plants with high nutritional value can be added to the herbal combination content of individuals following a vegetarian or vegan diet.
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