The determination of the effect of some 1,3,4 thiadiazole derivatives on biochemical content (Fatty Acids, Sterols, Lipophilic Vitamins) in rat liver

Parlak, Akif Evren; Karagozoglu, Yusuf; Alayunt, Naci Ömer; Türkoğlu, Semra; Karatepe, Mustafa; Koparır, Metin

doi:10.14715/cmb/2018.64.3.6

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…In a study brought about by Parlak et al (2018) investigated effects of hydroxyurea derivative 1,3,4thiadiazoles on fatty acids and lipophilic vitamins in rats liver. In this study, it was indicated that, while amounts of oleic acid (18: 1, n-9) and monounsaturated fatty acids (MUFA) increased significantly in Mn complex group compared to the control group, arachidonic acid amount (20: 4, n-6) in ligand group increased significantly, in addition, α-tocopherol amounts and K 2 and D 3 vitamins increased significantly in all groups compared to the control group, increases of αtocopherol amounts in both Mn and Cr complex groups were found closer to each other compared to the control group, and retinol amount in Mn complex group was lower compared to other groups.…”

Section: J Cell Neurosci Oxidmentioning

confidence: 99%

Relationship between some element levels and oxidative stress parameters in rats liver treated with hydroxyurea derivative compounds

Karagozoglu

Parlak

Alayunt

et al. 2019

Journal of Cellular Neuroscience and Oxidative Stress

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Journal of Cellular Neuroscience and Oxidative Stress is an online journal that publishes original research articles, reviews and short reviews on the molecular basis of biophysical, physiological and pharmacological processes that regulate cellular function, and the control or alteration of these processes by the action of receptors, neurotransmitters, second messengers, cation, anions, drugs or disease. Areas of particular interest are four topics. They are; A-Ion Channels (Na +-K + Channels, Clchannels, Ca 2+ channels, ADP-Ribose and metabolism of NAD + , Patch-Clamp applications) B-Oxidative Stress (Antioxidant vitamins, antioxidant enzymes, metabolism of nitric oxide, oxidative stress, biophysics, biochemistry and physiology of free oxygen radicals) C-Interaction Between Oxidative Stress and Ion Channels in Neuroscience (Effects of the oxidative stress on the activation of the voltage sensitive cation channels, effect of ADP-Ribose and NAD + on activation of the cation channels which are sensitive to voltage, effect of the oxidative stress on activation of the TRP channels in neurodegenerative diseases such Parkinson's and Alzheimer's diseases) D-Gene and Oxidative Stress (Gene abnormalities. Interaction between gene and free radicals. Gene anomalies and iron. Role of radiation and cancer on gene polymorphism)

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Section: J Cell Neurosci Oxidmentioning

confidence: 99%

Relationship between some element levels and oxidative stress parameters in rats liver treated with hydroxyurea derivative compounds

Karagozoglu

Parlak

Alayunt

et al. 2019

Journal of Cellular Neuroscience and Oxidative Stress

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“…Thiadiazole derivatives and its metal compounds have antibacterial, antifungal, antitumoral, antiproliferative and antioxidant properties. The effects caused by thiadiazole ligand and its metal complexes upon the fatty acids and lipophilic vitamins in livers of rats were examined by Parlak et al [18]. Many methods were employed for the determination of 1,3,4-thiadiazoles.…”

Section: Introductionmentioning

confidence: 99%

Titrimetric and Spectrophotometric Determination of Some Thiadiazole Derivatives by Using Amplification Reactions

Barbooti¹,

Al-Bayati²,

Hussain³

2021

AJAC

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The principle of using amplification reactions of iodine was employed in this paper to estimate the thiadiazole derivatives on basis of their reactions with iodine I chloroform, removal of the excess iodine and determination of the resulting iodide, after oxidation to iodate. The overall reaction gave an amplification of the iodide that is (12) times larger for the compounds: 2-amino-5mercapto-1,3,4-thiadiazole (I); 2,5-dimercapto-1,3,4-thiadiaole (II) and 2,5diamino-1,3,4-thiadiazole (III) and (36) times for 2,5-dihydrazino-1,3,4thiadiazole (IV) and (6) times for 5-mercapto-2[(3[5'-nitro-2-'furyl]•methylene)amino]-1,3,4-thiadiazole (V) and 5-mercapto-2[(3[5'-nitro-2-'furyl]-prop-2-enylidene)amino]-1,3,4-thiadiazole (VI). By titration, 1-mL of standard thiosulfate solution was found equivalent to 0.108 mg of (I); 0.126 mg of (II), 0.16 mg of (III), 0.041 mg of (IV), 0.40 mg of (V) and 0.435 mg of (VI). Using the spectrophotometric detection for the amplification reaction gave high absorbance values at 605 nm for the blue starch-iodine complex. Beer's law was obeyed up to 4.0 ppm for compounds (I and II); 6.0 ppm for compounds (III, IV and VI) and 5.0 ppm for compound (V). The mechanism of the reactions was proposed and the analytical parameters were evaluated for both methods. The method was applied for synthetic samples of industrial importance. The recovery was comparable while the sensitivity and detection limits were better for the spectrophotometric detection.

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The determination of the effect of some 1,3,4 thiadiazole derivatives on biochemical content (Fatty Acids, Sterols, Lipophilic Vitamins) in rat liver

Cited by 2 publications

References 17 publications

Relationship between some element levels and oxidative stress parameters in rats liver treated with hydroxyurea derivative compounds

Relationship between some element levels and oxidative stress parameters in rats liver treated with hydroxyurea derivative compounds

Titrimetric and Spectrophotometric Determination of Some Thiadiazole Derivatives by Using Amplification Reactions

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