Occupational therapy often uses craft activities as therapeutic tools, but their therapeutic effectiveness has not yet been adequately demonstrated. The aim of this study was to examine changes in frontal midline theta rhythm (Fmθ) and autonomic nervous responses during craft activities, and to explore the physiological mechanisms underlying the therapeutic effectiveness of occupational therapy. To achieve this, we employed a simple craft activity as a task to induce Fmθ and performed simultaneous EEG and ECG recordings. For participants in which Fmθ activities were provoked, parasympathetic and sympathetic activities were evaluated during the appearance of Fmθ and rest periods using the Lorenz plot analysis. Both parasympathetic and sympathetic indices increased with the appearance of Fmθ compared to during resting periods. This suggests that a relaxed-concentration state is achieved by concentrating on craft activities. Furthermore, the appearance of Fmθ positively correlated with parasympathetic activity, and theta band activity in the frontal area were associated with sympathetic activity. This suggests that there is a close relationship between cardiac autonomic function and Fmθ activity.

Aggregation of the 43 kDa TAR DNA‐binding protein (TDP‐43) is a pathological hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). RNA binding and TDP‐43 N‐terminal domain dimerisation has been suggested to ameliorate TDP‐43 aggregation. However, the relationship between these factors and the solubility of TDP‐43 is largely unknown. Therefore, we developed new oligonucleotides that can recruit two TDP‐43 molecules and interfere with their intermolecular interactions via spatial separation. Using these oligonucleotides and TDP‐43‐preferable UG‐repeats, we uncovered two distinct mechanisms for modulating TDP‐43 solubility by RNA binding: One is N‐terminal domain dimerisation, and the other is the spatial separation of two TDP‐43 molecules. This study provides new molecular insights into the regulation of TDP‐43 solubility.

Introduction High heeled shoes have long been worn in society and they are known to cause biomechanical imbalances to not only the foot, but the whole musculoskeletal system. This study aims to show the detailed changes that happen to the shape of the transverse arch of the foot in high heels, using two different inclination degrees. Methods 68 women participated in this study. Two custom-made high heels were made with inclinations of 15 degrees and 30 degrees (cm). A weight-bearing ultrasound was used to assess the coronal view of the transverse arch in standing. ANOVA and Tuckey tests were used to compare the results between 0 degrees, 15 degrees and 30 degrees inclinations. Results The transverse arch height was slightly increased as the heel height increased (0DI-15DI: p = 0.5852 / 15DI-30DI: p = 0.395 / 0DI-30DI: p = 0.0593). The transverse arch length (0DI-15DI: p = 0.0486 / 15DI-30DI: p = 0.0004 / 0DI-30DI: p = 0.1105) and the area under the metatarsal heads (0DI-15DI: p = 0.0422 / 15DI-30DI: p = 0.0180 / 0DI-30DI: p = 0.9463) significantly decreased as the heel height increased. Discussion The main changes were viewed in the 30 degrees inclinations compared to 0 degrees inclination. When the toes are dorsiflexed in high heels, it stimulates the Windlass mechanism which in turn stiffens the plantar fascia and adducts the metatarsal heads, while the soft tissues shrink in response to loads.

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Anxiety increases self-focused attention and rumination. Individuals with anxiety are sensitive to being watched by others, as being watched provokes self-referential processing and induces thoughts regarding others perceptions of oneself. However, whether the neural sensitivity to being watched depends on the level of anxiety remains unclear.We investigated the relationship between anxiety and the neural sensitivity to being watched by others.The anxiety of 25 healthy participants (mean age standard deviation, 23.08 1.71 years; 12 men and 13 women) was evaluated using the Spielberger StateTrait Anxiety Inventory. Resting state electroencephalography data was collected under the alone condition and the condition of being watched by another person. By subtracting the phase lag value between the two conditions, we determined the alterations in participants functional networks when they were being watched. We then found the correlation between the Spielberger StateTrait Anxiety Inventory scores and reactivity of functional connectivity when being watched.The score of state anxiety was significantly correlated with increased phase lag values in the left precuneus, bilateral caudal anterior cingulate cortex, and right rostral middle frontal cortex in the beta band (p< 0.05). We found no significant correlation between the trait anxiety scores and altered phase lag values.Functional connectivity may be involved in the default mode network relevant to self-referential processing and the dorsal attentional network. Our results suggest that self-focused mental processing and sensitivity to being watched by others could be common in people with anxiety, thus expanding the current understanding of the cognitive mechanisms behind anxiety.