We present experimental results on the in vitro and in vivo study of dye diffusion into human skin and hair follicles. We have studied some commercially available dyes for potential using in the laser selective thermolysis. The degree and the depth of hair follicle dyeing inside the skin were determined. For hairs in different stages the sebaceous gland was stated as a reservoir for a dye administration. It was found that the penetration depth of dyes is about 1.2 mm from the skin surface. We have developed the biocompatible Indocyanine Green lotions and the method for in vivo dyeing and dye in depth monitoring. Shift on 16-21 nm of absorption peak of Indocyanine Green to the longer wavelengths due to Indocyanine Green binding with cell proteins in the human skin was found.
We present experimental results on optical properties of the rat skin controlled by administration of osmotically active chemical, such as glycerol. In vivo reflectance and in vitro reflectance and transmittance spectra of the rat skin were measured. Results of experimental study of influence of glycerol on reflectance spectra of the rat skin are presented. The significant increase of transmittance and decrease of reflectance of the rat skin under action of osmotical agent are demonstrated. Basing on mathematical modeling the optical parameters of the rat skin are determined.
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