RESUMO Introdução:No Brasil, um a cada nove pacientes hospitalizados é vítima de acidente de trânsito. O impacto desses números implicam repercussões econômicas, sociais e administrativas. Objetivos: Levantar dados epidemiológicos sobre as vítimas de eventos traumáticos com motocicletas encaminhadas para um hospital terciário (Conjunto Hospitalar de Sorocaba), descrever as lesões encontradas e discutir o impacto na qualidade de vida dessas vítimas. Método: estudo prospectivo que incluiu vítimas de trauma envolvidas em acidentes com motocicletas, no período de abril a setembro de 2013, referenciadas a um hospital de nível terciário. Para a coleta de dados, foi elaborada ficha padronizada com escores de trauma, seu mecanismo e descrição das lesões. Resultados: Um total de 143 pacientes foram analisados: 83,2% homens e 16,8% mulheres, com o predomínio do grupo etário entre 20-29 anos (49,6%). O uso de capacete foi relatado em 98,5% dos casos. O gênero masculino representou cerca de 86% na categoria de condutor da motocicleta. Os principais mecanismos de trauma foram colisões (72,7%), seguidas de queda da motocicleta (15,4%). Quanto às lesões, as mais encontradas foram as escoriações (72,9%) e os ferimentos corto-contusos (13,8%). Os segmentos anatômicos mais acometidos foram os membros superiores e inferiores, representando 83% dos casos. Pacientes foram avaliados quanto ao Revised Trauma Score (RTS); as vítimas com RTS=12 somaram 97,9%, o que sugere gravidade relativamente leve da maioria dos pacientes. Conclusões: Os achados do presente estudo, quanto ao padrão majoritário das vítimas de acidentes envolvendo motocicletas, são compatíveis com a literatura. O predomínio da população economicamente ativa do país em eventos tão onerosos e incapacitantes como os acidentes com motocicletas implica na necessidade de novas estratégias na gestão do trânsito e da saúde pública. Palavras-chave: acidentes de trânsito; ferimentos e lesões; violência. ABSTRACT Introduction:In Brazil, at least one in nine hospitalized patients was a traffic accident victim. The impact of these numbers implies economic, social and administrative repercussions. Objectives: To raise epidemiological data on victims of traumatic events with motorcycles forwarded to a tertiary level hospital (Conjunto Hospitalar de Sorocaba) to describe the injuries and discuss the impact on quality of life of these victims. Method: Prospective study that included trauma victims from accidents with motorcycles, between April and September, 2013, referenced to a tertiary level hospital. For data collection, standardized form was drawn up with trauma scores, mechanism of trauma and description of injuries. Results: A total of 143 patients were analyzed: 83.2% men and 16.8% women, with the predominance of the age group between 20-29 years (49.6%). The use of helmets was reported in 98.5% of cases. The male gender accounted for about 86% in the category of the motorcycle driver. The main mechanisms of trauma were collisions (72.7%), followed by drop of motorcycle (15.4%)...
RESUMOObjetivo: Traduzir a versão breve da Affective Neuroscience Personality Scales para a língua portuguesa, adaptando essa nova versão transculturalmente. Método: A escala foi traduzida inicialmente para o português, seguida de uma tradução inversa por um nativo da língua inglesa juntamente com a opinião de quatro especialistas. Esse processo permitiu a conclusão de uma escala pré-final, que foi novamente passada para o português por outro tradutor nativo americano e aplicada em um grupo-piloto de 30 estudantes universitários da Faculdade de Ciências Médicas e da Saúde da Pontifícia Universidade Católica de São Paulo. Posteriormente, eles foram entrevistados e, com base nos dados obtidos, foi elaborada a versão final da escala. Para a análise estatística, foram utilizadas as correlações de Spearman e o coeficiente alfa de Cronbach a fim de verificar o grau de consistência interna das questões. Resultados: Após a realização de todo o processo e das entrevistas, obteve-se uma escala com 30 itens, índice alfa de Cronbach de 0,192 e uma tradução possível de ser compreendida tanto pelos médicos quanto pelos pacientes, conforme apontado pelos entrevistados. Conclusão: Tem-se um questionário de avaliação emocional da personalidade com base em substratos neuronais traduzido e adaptado transculturalmente para o português brasileiro, caracterizando-se como uma ferramenta que oferece a possibilidade de conectar a personalidade humana às funções neurobiológicas. Palavras-chave: tradução; inquéritos e questionários; personalidade. ABSTRACT Objective:To translate a short version of the Affective Neuroscience Personality Scales into Portuguese language, adapting this new version transculturally. Method: The scale was initially translated into Portuguese, followed by an inverse translation by an English native, along with the opinion of four experts. This process allowed to conclude a prefinal scale, which was translated back to Portuguese by another Native-speaker American translator and applied into a pilot group of 30 university students from the Medical School of the Catholic University of São Paulo (PUC-SP). Subsequently, they were interviewed and the final version of the scale was elaborated from the data obtained. For the statistical analysis, we used the Spearman correlations and Cronbach's alpha coefficient to verify the degree of internal consistency of the questions. Results: After completing the whole process and interviews, a scale was obtained with 31 items, Cronbach's alpha index of 0.192 and a translation that could be understood by both physicians and patients, as indicated by the interviewed. Conclusion: We have a personality emotional evaluation questionnaire based on neural substrates, translated and adapted transculturally into Brazilian Portuguese, characterized as a tool that offers the possibility of connecting human personality to neurobiological functions.
Capillaries play a critical role in cardiovascular function as the point ofexchange ofnutnents and waste products between tissues and circulation. A common problem for healthy volunteers examined during isolation, and for the patients suffering from heart failure is a quantitative estimation tissue oedema. Until now, objective assessment body fluids retention in tissues did not exist.Optical imaging of living capillaries is a challenging and medically important scientific problem.Goal of the investigation was to study dynamic of microcirculation parameters including tissue oedema in healthy volunteers during extended isolation and relative hypokinesia as a model of mission to the International Space Station. The other aim was to study dynamic of microcirculation parameters including tissue oedema in patients suffering from heart failure under treatment.Healthy volunteers and patients. We studied four healthy male subjects at the age of 41, 37, 40, and 48 before the experiment (June 1999), and during the 240-d isolation period starting from July 3, 1999. Unique hermetic chambers with artificial environmental parameters allowed performing this study with maximum similarity to real conditions in the International Space Station (155). With the regularity of 3 times a week at the same time, each subject recorded three video episodes with the total length of one-minute using the optical computerized capillaroscope for noninvasive measurement of the capillary diameters sizes, capillary blood velocity as well as the size ofthe perivascular zone. All this parameters of microcirculation determined during three weeks in 15 patients (10 male, 5 female, aged 62, 2±8,8) suffering from heart failure under Furosemid 40 mg 2 times a week, as diuretic. Results. About 1500 episodes recorded on laser disks and analyzed during this experiment. Every subject had wave-like variations of capillary blood velocity within the minute, week, and month ranges. It was found that the perivascular zone sizes rising during isolation correlate with body mass of subjects and probably depend on retention of body fluids in tissues. Computerized capillaroscopy provides a new opportunity for non-invasive quantitative estimation tissue oedema and suggests for exact management patients suffering from heart failure under diuretic treatment.
Objetivo: O estudo buscou analisar a aplicação do hidrogel de Poli (NIPAAm-co-AAc-co-HEMAPLDLA-co-TMC) in vivo, acompanhando as reações teciduais desencadeadas ao redor. Métodos: Os implantes desse polímero foram realizados por via injetável no tecido subcutâneo do dorso posterior de 21 ratos Wistar. Após o período de cinco, sete, dez, 15, 21 e 30 dias ocorreu o sacrifício dos animais e posterior análise histológica. Resultados: Ausência de inflamação no local do implante e presença de espaçamentos deixados em decorrência do implante (que foi removido em razão do processamento). A ausência de resposta inflamatória significativa inviabilizou a realização de uma análise estatística dela. Conclusão: O hidrogel Poli (NIPAAm-co-AAc-co-HEMAPLDLA-co-TMC) apresenta biocompatibilidade e potencial como material de preenchimento, sendo necessários maiores estudos para que se possa entender a sua termossensibilidade e localizá-lo sem a presença de corante.
An automatic device for high-temporal resolution of the process of erythrocytes sedimentation in blood was designed. The position of the boundary between red blood and plasma is registered each 30 sec in several pipettes simultaneously with ±10 mkm precision. Data are processed by a PC and presented as velocity-time curves (ESR-grams) and the curves describing time evolution of the boundary position. ESR-grams demonstrate non-monotonous character of erythrocytes sedimentation in blood. Blood of particular donor being in a stable physiological state taken on different days is characterized by similar ESR-grams. Pathological deviations from a normal physiological state are reflected in the shortening of duration of each process stage and increasing of average sedimentation rate. Intravenous infusion of some medical preparations may lead either to improving (prolonging of macrokinetic stages, decreasing of sedimentation rate), or to worsening of studied parameters depending on an individual. The low extent of blood dilution with saline in vitro lead as a rule to decreasing of sedimentation rate and improving of microkinetic parameters of the process. Adding of highly diluted hydrogen peroxide to blood samples of patients resulted in the improving of sedimentation kinetics. ESR-graphy may widen opportunities of practical medicine in diagnostics, prognostics and drug therapy.
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