A convenient and effective method of ruthenium‐catalyzed C−H/N−H annulations using vinylene carbonate as oxidizing acetylene surrogate has been disclosed. This method is scalable and compatible with a wide range of functional groups, providing a step‐economical access to indole synthesis Preliminary mechanistic studies provided support for a reversible, acetate‐assisted C−H ruthenation, along with a subsequent olefin insertion.
Herein, we report a highly efficient ruthenium-catalyzed peri-selective C(sp 2 )−H acylmethylation of 1-naphthols with α-carbonyl sulfoxonium ylides by utilizing hydroxyl as a weakly coordinating directing group. This new method imparts good reactivity, excellent chemo-and regioselectivity, and broad functional group tolerance and involves mild reaction conditions. The C− H acylmethylated products can be readily cyclized into fluorescent annulated pyrans by a one-pot process.
A convenient and effective method of palladium-catalyzed CÀ H selenylation of the 2-aryl acetamides assisted with removable 8-aminoquinoline with readily available diselenides and selenyl chlorides has been developed. This selenylation reaction is scalable and tolerates a wide range of functional groups, providing a straightforward way of the preparing unsymmetrical diaryl selenides and dibenzoselene-pinone. Preliminary mechanistic studies indicated that a single-electron transfer type mechanism and facile CÀ H metalation are operative.
Herein, we report a general and efficient method for the palladium‐catalyzed remote C(sp2)−H difluoroalkylation of N‐aryloxazolidinone derivatives with commercially available difluoroalkyl bromide. This method tolerates a wide range of functional groups with 26 examples in up to 96 % yields. Moreover, it proceeds with complete para‐selectivity. Preliminary mechanistic studies indicated that a single electron transfer process likely involved in this transformation.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.