Purpose: Rhabdoid tumors are highly aggressive pediatric tumors that are usually refractory to available treatments. The purpose of this study was to evaluate the therapeutic potential of two oncolytic viruses, myxoma virus (MV) and an attenuated vesicular stomatitis virus (VSV : 25 days versus 21days, log-rank test, P = 0.0036; MV: median survival not reached versus 21 days, log-rank test, P = 0.0007). Most of the MV-treated animals (4 of 6; 66.7%) were alive and apparently ''cured'' when the experiment was arbitrarily ended (>180 days). Conclusions: These results suggest that VSV DM51 and MV could be novel effective therapies against human rhabdoid tumor.
Background: Hospitalization is a significant outcome measurement for maintenance hemodialysis pantients. Trimethylamine-N-oxide (TMAO), created by gut microflora from dietary L-carnitine and choline, cleared by the kidney, has been implicated in the causation of cardiovascular diseases in patients with chronic kidney disease. However, whether it associates with hospitalization risk for these patients is unclear. Methods: In this study, 69 patients undergoing outpatient dialysis were enrolled. Enzyme-linked immunosorbent assay was used to quantitate the baseline plasma TMAO levels in patients. The patients were divided into a high TMAO level group (TMAO ! 15 lmol/L) and a low TMAO level group (TMAO < 15 lmol/L). During the 1-year follow-up, 1-year dialysis-related data and all-cause hospitalization events were recorded. Results: The incidence of hospitalization events was significantly higher in the high TMAO level group than in the low TMAO level group (91 per 100 patient-year vs. 32 per 100 patient-year). The Kaplain-Meier survaial analysis showed that the incidence of hospitalization events in the high TMAO level group was significantly higher than that in the low TMAO level group (log-rank p ¼ 0.0004). After adjustment age, sex, CK-MB and albumin, the results of multivariate Cox proportional hazard analysis showed that high TMAO level was an independent risk factor for hospitalization in maintenance hemodialysis patients. Conclusion: TMAO is an independent risk factor for hospitalization events in patients receiving maintenance hemodialysis. It may be a new therapeutic target for improving the outcomes of these patients.
We evaluate the realization of a novel geometry of a guided atom interferometer based on a high temperature superconducting microstructure. The interferometer type structure is obtained with a guiding potential realized by two current carrying superconducting wires in combination with a closed superconducting loop sustaining a persistent current. We present the layout and realization of our superconducting atom chip. By employing simulations we discuss the critical parameters of the interferometer guide in particular near the splitting regions of the matter waves. Based on measurements of the relevant chip properties we discuss the application of a compact and reliable on-chip atom interferometer.
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